Gene Symbol | MTMR4 |
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Entrez Gene | 9110 |
Alt Symbol | FYVE-DSP2, ZFYVE11 |
Species | Human |
Gene Type | protein-coding |
Description | myotubularin related protein 4 |
Other Description | FYVE domain-containing dual specificity protein phosphatase 2|myotubularin-related protein 4|zinc finger FYVE domain-containing protein 11|zinc finger, FYVE domain containing 11 |
Swissprots | Q9NYA4 Q8IV27 Q9Y4D5 D3DTZ6 |
Accessions | EAW94454 EAW94455 Q9NYA4 AB014547 BAA31622 AF264717 AAF72539 AI538945 AK308877 BC035609 AAH35609 DR003190 XM_005257784 XP_005257841 XM_005257785 XP_005257842 XM_005257786 XP_005257843 XM_006722168 XP_006722231 XM_011525460 XP_011523762 NM_004687 NP_004678 |
Function | Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3). {ECO:0000269|PubMed:11302699}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11302699}. Membrane {ECO:0000269|PubMed:11302699}; Peripheral membrane protein {ECO:0000269|PubMed:11302699}. Note=Localized to perinuclear region. |
Tissue Specificity | Expressed in brain, heart, kidney, spleen, liver, colon, testis, muscle, placenta, thyroid gland, pancreas, ovary, prostate, skin, peripheral blood, and bone marrow. {ECO:0000269|PubMed:11302699}. |
MTMR4 CRISPR/Cas9 KO Plasmid (h) - sc-409731 from Santa Cruz Biotechnology
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MTMR4 HDR Plasmid (h) - sc-409731-HDR from Santa Cruz Biotechnology
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MTMR4 Double Nickase Plasmid (h) - sc-409731-NIC from Santa Cruz Biotechnology
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MTMR4 Double Nickase Plasmid (h2) - sc-409731-NIC-2 from Santa Cruz Biotechnology
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MTMR4 CRISPR Activation Plasmid (h) - sc-409731-ACT from Santa Cruz Biotechnology
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MTMR4 CRISPR Activation Plasmid (h2) - sc-409731-ACT-2 from Santa Cruz Biotechnology
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MTMR4 Lentiviral Activation Particles (h) - sc-409731-LAC from Santa Cruz Biotechnology
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MTMR4 Lentiviral Activation Particles (h2) - sc-409731-LAC-2 from Santa Cruz Biotechnology
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MTMR4 siRNA (h) - sc-61090 from Santa Cruz Biotechnology
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MTMR4 shRNA Plasmid (h) - sc-61090-SH from Santa Cruz Biotechnology
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MTMR4 shRNA (h) Lentiviral Particles - sc-61090-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU009391 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0334 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0336 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0335 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14720 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14720 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10957 from Sigma-Aldrich
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MTMR4 siRNA (Human) - CRH6019 from Cohesion Biosciences
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MTMR4 RNAi - H00009110-R02 from Novus Biologicals
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shRNA set against Human Mtmr4 (NM_004687.4) - SHH346516 from Creative biogene
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Human MTMR4 siRNA - orb266521 from Biorbyt
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MTMR4 shRNA Plasmid (Human) - CHH6019 from Cohesion Biosciences
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MTMR4 miRNA 3'UTR clone - MiUTR4H-TG05713 from Creative biogene
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