| Gene Symbol | CADPS |
|---|---|
| Entrez Gene | 8618 |
| Alt Symbol | CADPS1, CAPS, CAPS1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | Ca++-dependent secretion activator |
| Other Description | CAPS-1|Ca2+-dependent activator protein for secretion|Ca2+-dependent secretion activator|Ca2+-regulated cytoskeletal protein|calcium-dependent activator protein for secretion 1|calcium-dependent secretion activator 1 |
| Swissprots | Q6GQQ6 Q13339 A6NF60 Q9ULU8 Q8NFR0 Q8N3M7 Q8N2Z5 Q96BC2 |
| Accessions | EAW65405 EAW65406 EAW65407 EAW65408 EAW65409 EAW65410 EAW65411 Q9ULU8 AB032947 BAA86435 AB593079 BAJ84019 AF458662 AAM61861 AK000873 AK127506 AL833895 CAD38751 BC015754 AAH15754 BC029460 AAH29460 BC035100 BC072684 AAH72684 BC131731 AAI31732 BX647166 R54020 U36448 AAA79701 XM_006713378 XP_006713441 XM_011534171 XP_011532473 XM_011534172 XP_011532474 XM_011534173 XP_011532475 XM_011534174 XP_011532476 XM_011534175 XP_011532477 XM_011534176 XP_011532478 XM_011534177 XP_011532479 XM_011534178 XP_011532480 XM_011534179 XP_011532481 XM_011534180 XP_011532482 XM_011534181 XP_011532483 XM_011534182 XP_011532484 XM_011534183 XP_011532485 XM_011534184 XP_011532486 XM_011534185 XP_011532487 XM_011534186 XP_011532488 XM_011534187 XP_011532489 XM_011534188 XP_011532490 XM_011534189 XP_011532491 XM_011534190 XP_011532492 XM_011534191 XP_011532493 XM_011534192 XP_011532494 XM_011534193 XP_011532495 XM_011534194 XP_011532496 XM_011534195 XP_011532497 XM_011534196 XP_011532498 XM_011534197 XP_011532499 XM_011534198 XP_011532500 XM_011534199 XP_011532501 XM_011534200 XP_011532502 XM_011534201 XP_011532503 XM_011534202 XP_011532504 XM_011534203 XP_011532505 NM_003716 NP_003707 NM_183393 NP_899630 NM_183394 NP_899631 |
| Function | Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Preferentially binds to DCVs but not to SVs. Binds phosphoinosides, with a strong selectivity for PtdIns(4,5)P2 over PtdIns(3,4,5)P3. Probably localizes to different vesicles compared to CADPS2 (By similarity). {ECO:0000250}. |
| Tissue Specificity | Specifically expressed in neural and endocrine secretory tissues. Expressed in brain and pancreas and at low level in heart. Also expressed in fetal heart, cerebellum, cerebral cortex, medulla, occipital pole, frontal and temporal lobes, and putamen, as well as weak expression in spinal cord. {ECO:0000269|PubMed:12659812}. |