CADPS

Gene Symbol CADPS
Entrez Gene 8618
Alt Symbol CADPS1, CAPS, CAPS1
Species Human
Gene Type protein-coding
Description Ca++-dependent secretion activator
Other Description CAPS-1|Ca2+-dependent activator protein for secretion|Ca2+-dependent secretion activator|Ca2+-regulated cytoskeletal protein|calcium-dependent activator protein for secretion 1|calcium-dependent secretion activator 1
Swissprots Q6GQQ6 Q13339 A6NF60 Q9ULU8 Q8NFR0 Q8N3M7 Q8N2Z5 Q96BC2
Accessions EAW65405 EAW65406 EAW65407 EAW65408 EAW65409 EAW65410 EAW65411 Q9ULU8 AB032947 BAA86435 AB593079 BAJ84019 AF458662 AAM61861 AK000873 AK127506 AL833895 CAD38751 BC015754 AAH15754 BC029460 AAH29460 BC035100 BC072684 AAH72684 BC131731 AAI31732 BX647166 R54020 U36448 AAA79701 XM_006713378 XP_006713441 XM_011534171 XP_011532473 XM_011534172 XP_011532474 XM_011534173 XP_011532475 XM_011534174 XP_011532476 XM_011534175 XP_011532477 XM_011534176 XP_011532478 XM_011534177 XP_011532479 XM_011534178 XP_011532480 XM_011534179 XP_011532481 XM_011534180 XP_011532482 XM_011534181 XP_011532483 XM_011534182 XP_011532484 XM_011534183 XP_011532485 XM_011534184 XP_011532486 XM_011534185 XP_011532487 XM_011534186 XP_011532488 XM_011534187 XP_011532489 XM_011534188 XP_011532490 XM_011534189 XP_011532491 XM_011534190 XP_011532492 XM_011534191 XP_011532493 XM_011534192 XP_011532494 XM_011534193 XP_011532495 XM_011534194 XP_011532496 XM_011534195 XP_011532497 XM_011534196 XP_011532498 XM_011534197 XP_011532499 XM_011534198 XP_011532500 XM_011534199 XP_011532501 XM_011534200 XP_011532502 XM_011534201 XP_011532503 XM_011534202 XP_011532504 XM_011534203 XP_011532505 NM_003716 NP_003707 NM_183393 NP_899630 NM_183394 NP_899631
Function Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Preferentially binds to DCVs but not to SVs. Binds phosphoinosides, with a strong selectivity for PtdIns(4,5)P2 over PtdIns(3,4,5)P3. Probably localizes to different vesicles compared to CADPS2 (By similarity). {ECO:0000250}.
Tissue Specificity Specifically expressed in neural and endocrine secretory tissues. Expressed in brain and pancreas and at low level in heart. Also expressed in fetal heart, cerebellum, cerebral cortex, medulla, occipital pole, frontal and temporal lobes, and putamen, as well as weak expression in spinal cord. {ECO:0000269|PubMed:12659812}.

CAPS-1 (H-60) - sc-135028 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CAPS-1 (H-60): sc-135028. Western blot analysis of CAPS-1 expression in rat brain tissue extract.

CAPS-1 (C-16) - sc-65010 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CAPS-1 (P-18) - sc-65012 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CAPS-1 (P-18): sc-65012. Western blot analysis of CAPS-1 expression in rat brain tissue extract.

CAPS-1 (G-12) - sc-377279 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CAPS-1 (G-12): sc-377279. Western blot analysis of CAPS-1 expression in rat brain tissue extract.

CAPS-1 (S-17) - sc-65013 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-CAPS1 antibody - ab32011 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CAPS1 antibody (ab32011) at 1 µg/mlLane 1 : Brain (Rat) Tissue Lysate Lane 2 : Brain (Mouse) Tissue Lysate Lane 3 : Heart (Mouse) Tissue Lysate Lane 4 : Brain (Rat) Tissue Lysate with CAPS1 peptide (ab32785) at 1 µg/mlLane 5 : Brain (Mouse) Tissue Lysate with CAPS1 peptide (ab32785) at 1 µg/mlLane 6 : Heart (Mouse) Tissue Lysate with CAPS1 peptide (ab32785) at 1 µg/mlLysates/proteins at 10 µg per lane.SecondaryIRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/10000 dilutionPerformed under reducing conditions.

Anti-CAPS1 antibody - ab69795 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of CAPS1 in Human brain tissue with ab69795 at 20 ug/mL.

Anti-CAPS1 antibody - ab69797 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of CAPS1 in Human brain tissue with ab69797 at 20 ug/mL.

Anti-CAPS1 antibody - ab32787 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CAPS1 antibody (ab32787) at 1 µg/mlLane 1 : Brain (Rat) Tissue Lysate at 10 µgLane 2 : Brain (Mouse) Tissue Lysate at 10 µgLane 3 : Heart (Mouse) Tissue Lysate at 10 µgLane 4 : Brain (Rat) Tissue Lysate with Rat CAPS1 peptide (ab32786) at 1 µg/mlLane 5 : Brain (Mouse) Tissue Lysate at 10 µg with Rat CAPS1 peptide (ab32786) at 1 µg/mlLane 6 : Heart (Mouse) Tissue Lysate at 10 µg with Rat CAPS1 peptide (ab32786) at 1 µg/mlSecondaryIRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/10000 dilutionPerformed under reducing conditions.

Anti-CAPS1 antibody - C-terminal - ab194373 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Anti-CAPS1 antibody - C-terminal (ab194373) at 1/500 dilution + Y79 cell lysate at 50 µgdeveloped using the ECL technique

Anti-CADPS Antibody (N-Terminus) IHC-plus™ - LS-B4591 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CADPS antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4591 concentration 5 ug/ml.

Anti-CADPS Antibody (aa542-591) - LS-C201739 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human U937. CADPS antibody dilution 1.0 ug/ml.

Anti-CADPS Antibody (C-Terminus) IHC-plus™ - LS-B4590 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CADPS antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4590 concentration 5 ug/ml.

CADPS Antibody - NBP1-77324 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: CADPS Antibody [NBP1-77324] - Rat brain tissue lysate with CADPS antibody at (A) 0.25 and (B) 0.5 ug/ml.

CADPS Antibody - NBP1-77323 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: CADPS Antibody [NBP1-77323] - Rat brain tissue lysate with CADPS antibody at (A) 0.5 and (B) 1 ug/ml.

CADPS Antibody - NBP2-38871 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CADPS Antibody [NBP2-38871] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10<br/>Lane 2: RT-4<br/>Lane 3: U-251 MG

CADPS Antibody - NBP1-71979 from Novus Biologicals

Prices $399.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: CADPS Antibody [NBP1-71979] - Staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

CADPS Antibody - H00008618-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: CADPS Antibody [H00008618-A01] - CADPS polyclonal antibody (A01), Lot # 060608JCS1 Western Blot analysis of CADPS expression in Y-79 ( Cat # L042V1 ).

Anti-CADPS antibody produced in rabbit - SAB2900789 from Sigma-Aldrich

Prices $465.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CADPS (C-Terminus), antibody produced in rabbit: <B>Cat. No. SAB2900789</B>: Anti-CADPS antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 μg/mL.

Anti-CAPS1 (ab1) antibody produced in rabbit - PRS4559 from Sigma-Aldrich

Prices $347.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CAPS1: <B>Cat. No. PRS4559</B> Immunohistochemistry of CAPS1 in human brain with CAPS1 antibody at 5 μg/mL.

Anti-CADPS antibody produced in rabbit - HPA053835 from Sigma-Aldrich

Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CADPS: <B>Cat. No. HPA053835</B>: Immunohistochemical staining of human prostate shows strong cytoplasmic staining with moderate nuclear positivity in glandular cells.

Anti-CAPS1 (ab2) antibody produced in rabbit - PRS4561 from Sigma-Aldrich

Prices $347.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CAPS1: <B>Cat. No. PRS4561</B> Immunohistochemistry of CAPS1 in human brain with CAPS1 antibody at 5 μg/mL.

Anti-CADPS antibody produced in rabbit - SAB2900788 from Sigma-Aldrich

Prices $465.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CADPS, antibody produced in rabbit: <B>Cat. No. SAB2900788</B>: Anti-CADPS antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 μg/mL.

CAPS1 Antibody - C-terminal region (ARP59499_P050) - ARP59499_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CADPS2 Antibody - N-terminal region (ARP59502_P050) - ARP59502_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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