Gene Symbol | Hes1 |
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Entrez Gene | 15205 |
Alt Symbol | Hry, bHLHb39 |
Species | Mouse |
Gene Type | protein-coding |
Description | hairy and enhancer of split 1 (Drosophila) |
Other Description | transcription factor HES-1 |
Swissprots | P35428 |
Accessions | BAA03931 EDK97718 P35428 AK132536 BAE21226 AK133538 BAE21713 BC018375 AAH18375 BC051428 AAH51428 XM_006521797 XP_006521860 NM_008235 NP_032261 |
Function | Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity). Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross- link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus. |
Tissue Specificity | Expressed at high levels in undifferentiated neural precursor cells, but the level of expression decreases as neural differentiation proceeds. |
Top Pathways | Notch signaling pathway, Maturity onset diabetes of the young, Fanconi anemia pathway |
HES-1 Antibody - NBP2-22429 from Novus Biologicals
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Mouse-Hes1-Antibody-C-term - AP21019c from Abgent, a WuXi AppTec company
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Mouse-Hes1-Antibody-Center - AP20925a from Abgent, a WuXi AppTec company
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HES1 antibody - AP55327PU-N from Acris Antibodies
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Anti-HES1 (C-terminal) polyclonal antibody - DPABH-28069 from Creative Diagnostics
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Anti-HES-1 Antibody - ABN1386 from EMD Millipore
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Transcription factor HES-1 antibody - pab0355-P from Covalab
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Hes1 Antibody - middle region (OAAB18885) - OAAB18885 from Aviva Systems Biology
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Hes1 Antibody - C-terminal region (OAAB18979) - OAAB18979 from Aviva Systems Biology
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Hes1, Polyclonal Antibody - MBS9212794 from MyBioSource
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Hes1, Polyclonal Antibody - MBS9213092 from MyBioSource
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Hes1 antibody - orb306165 from Biorbyt
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anti-HES1 antibody (Center) - ARG55618 from Arigo Biolaboratories |
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Hes1 Antibody (F52879) - F52879 from NSJ Bioreagent
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Hes1 Antibody (F53006) - F53006 from NSJ Bioreagent
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HES1 Antibody FITC Conjugated - C04399F from Signalway Antibody
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HES1 Antibody Biotin Conjugated - C04399B from Signalway Antibody
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HES1 Antibody HRP Conjugated - C04399H from Signalway Antibody
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Hes1 antibody - orb306289 from Biorbyt
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Rat Anti-HES1 monoclonal antibody, clone IT406B - CABT-RM152 from Creative Diagnostics
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