Gene Symbol | Hes1 |
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Entrez Gene | 15205 |
Alt Symbol | Hry, bHLHb39 |
Species | Mouse |
Gene Type | protein-coding |
Description | hairy and enhancer of split 1 (Drosophila) |
Other Description | transcription factor HES-1 |
Swissprots | P35428 |
Accessions | BAA03931 EDK97718 P35428 AK132536 BAE21226 AK133538 BAE21713 BC018375 AAH18375 BC051428 AAH51428 XM_006521797 XP_006521860 NM_008235 NP_032261 |
Function | Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity). Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross- link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus. |
Tissue Specificity | Expressed at high levels in undifferentiated neural precursor cells, but the level of expression decreases as neural differentiation proceeds. |
Top Pathways | Notch signaling pathway, Maturity onset diabetes of the young, Fanconi anemia pathway |
HES1 CRISPR/Cas9 KO Plasmid (m) - sc-420832 from Santa Cruz Biotechnology
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HES1 HDR Plasmid (m) - sc-420832-HDR from Santa Cruz Biotechnology
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HES1 Double Nickase Plasmid (m) - sc-420832-NIC from Santa Cruz Biotechnology
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HES1 Double Nickase Plasmid (m2) - sc-420832-NIC-2 from Santa Cruz Biotechnology
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HES1 CRISPR Activation Plasmid (m) - sc-420832-ACT from Santa Cruz Biotechnology
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HES1 CRISPR Activation Plasmid (m2) - sc-420832-ACT-2 from Santa Cruz Biotechnology
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HES1 Lentiviral Activation Particles (m) - sc-420832-LAC from Santa Cruz Biotechnology
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HES1 Lentiviral Activation Particles (m2) - sc-420832-LAC-2 from Santa Cruz Biotechnology
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HES1 siRNA (m) - sc-37939 from Santa Cruz Biotechnology
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HES1 shRNA Plasmid (m) - sc-37939-SH from Santa Cruz Biotechnology
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HES1 shRNA (m) Lentiviral Particles - sc-37939-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN33192 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33192 from Sigma-Aldrich
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HES1 siRNA (Mouse) - CRM1805 from Cohesion Biosciences
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HES1 - MBS8212269 from MyBioSource
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shRNA set against Mouse HES1 (NM_008235.2) - SHH311681 from Creative biogene
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shRNA set against Mouse Hes1(NM_008235.2) - SHH118793 from Creative biogene
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Mouse HES1 siRNA - orb281281 from Biorbyt
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HES1 shRNA Plasmid (Mouse) - CHM1805 from Cohesion Biosciences
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HES1 miRNA 3'UTR clone - MiUTR1M-05602 from Creative biogene
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