MADCAM1

Gene Symbol	MADCAM1
Entrez Gene	8174
Alt Symbol	MACAM1
Species	Human
Gene Type	protein-coding
Description	mucosal vascular addressin cell adhesion molecule 1
Other Description	MAdCAM-1|hMAdCAM-1|mucosal addressin cell adhesion molecule 1|mucosal addressin cell adhesion molecule-1
Swissprots	Q5UGI7 A5PKV4 O60222 O75867 B2RPL9 Q13477
Accessions	AAC51354 AAC62844 EAW61194 EAW61195 Q13477 AK092211 AY732484 AAV33123 AY819760 AAV68345 BC136408 AAI36409 BC137506 AAI37507 BC137507 AAI37508 BC142629 AAI42630 BC144065 AAI44066 DB323303 DQ076657 AAY82472 U43628 AAB02194 U82483 AAC13661 NM_130760 NP_570116 NM_130762 NP_570118
Function	Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L- selectin binding.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes. {ECO:0000269|PubMed:8609404, ECO:0000269|PubMed:8989586}.
Top Pathways	Cell adhesion molecules (CAMs), Intestinal immune network for IgA production

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MAdCAM-1 Antibody Blocking Peptide - LS-E23121 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MAdCAM-1 Fc Chimera, CF - 6056-MC-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

MADCAM1 fusion protein - Ag16184 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human Mucosal Vascular Addressin Cell Adhesion Molecule 1, Fc-tagged - MADCAM1-5684H from Creative Biomart Category Protein Source Murine myeloma cellline, NS0-derived.

Recombinant Human MADCAM1, MYC/DDK-tagged - MADCAM1-5690H from Creative Biomart Category Protein Source HEK293 Species Human

Recombinant Human MADCAM1, Fc Chimera - MADCAM1-421H from Creative Biomart Category Protein Source NSO cells Species Human

Recombinant Mucosal Addressin Cell Adhesion Molecule 1 (MAdCAM1) - RPB521Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Mucosal Addressin Cell Adhesion Molecule 1 (MAdCAM1) - RPB521Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Mucosal Addressin Cell Adhesion Molecule 1 (MAdCAM1) - RPB521Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Mucosal Addressin Cell Adhesion Molecule 1 (MAdCAM1) - RPB521Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Mucosal addressin cell adhesion molecule 1(MADCAM1) - CSB-YP618776HU CSB-EP618776HU CSB-BP618776HU CSB-MP618776HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human MAdCAM-1 Fc Chimera Protein, CF - 6056-MC from R&D Systems Category Protein Prices $229.00 Sizes 50 µg Source Mouse myeloma cell line, NS0-derived Human MAdCAM-1 Met1-Gln333 Accession # AAY82472 IEGRMD Human IgG 1 (Pro100-Lys333) N-terminus C-terminus Species Human

MADCAM1 Peptide - abx164620 from Abbexa Category Peptide Species Human

MAdCAM1 (transcript variant 2) - TP312381 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

MAdCAM1 (transcript variant 1) - TP319060 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Recombinant Homo sapiens (Human) Mucosal addressin cell adhesion molecule 1 - CSB-EP618776HU from Cusabio Category Protein Source E.coli Species Human

MADCAM1 Peptide, Human - M34GP09066H from Creative Peptides Category Peptide Source Synthetic. Species Human

MADCAM1 Recombinant Protein (OPCA03443) - OPCA03443 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

Recombinant Homo sapiens (Human) Mucosal addressin cell adhesion molecule 1 - AP73523 from Signalway Antibody Category Protein Prices $105.00 Sizes 10 µg Source E.coli Species Human

Mucosal addressin cell adhesion molecule 1, Recombinant Protein - MBS9423114 from MyBioSource Category Protein Prices $165.00 Sizes 10 µg Source E Coli Species Human

Mucosal addressin cell adhesion molecule 1, Recombinant Protein - MBS1282932 from MyBioSource Category Protein Prices $180.00, $490.00, $715.00, $950.00, $1,170.00, $1,170.00, $1,170.00, $1,400.00, $1,860.00, $1,860.00, $1,860.00, $2,760.00 Sizes 50 µg (E-Coli), 200 µg (E-Coli), 500 µg (E-Coli), 50 µg (Baculovirus), 1 mg (E-Coli), 50 µg (Mammalian-Cell), 500 µg (Yeast), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Human MADCAM1 protein - orb358699 from Biorbyt Category Protein Species Human

MADCAM-1 peptide - orb72939 from Biorbyt Category Peptide

Recombinant Human MADCAM1 Protein (19-317 aa), His-Myc-tagged - MADCAM1-2537H from Creative Biomart Category Protein Source Yeast Species Human

Recombinant Human MADCAM1 protein, His/sumo-tagged - MADCAM1-3943H from Creative Biomart Category Protein Source E. coli Species Human

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