Gene Symbol | MED10 |
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Entrez Gene | 84246 |
Alt Symbol | L6, NUT2, TRG20 |
Species | Human |
Gene Type | protein-coding |
Description | mediator complex subunit 10 |
Other Description | TRG-17|TRG-20|mediator of RNA polymerase II transcription subunit 10|mediator of RNA polymerase II transcription, subunit 10|transformation-related gene 17 protein|transformation-related gene 20 protein |
Swissprots | C6G491 Q9BTT4 |
Accessions | ACS13739 EAX08110 Q9BTT4 AA648258 AK075493 AY277599 AAQ18038 AY453397 AAS47514 AY598325 AAT06736 BC003353 AAH03353 BI597082 NM_032286 NP_115662 |
Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. |
Subcellular Location | Nucleus {ECO:0000305}. |
Med10 CRISPR/Cas9 KO Plasmid (h) - sc-407658 from Santa Cruz Biotechnology
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Med10 HDR Plasmid (h) - sc-407658-HDR from Santa Cruz Biotechnology
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Med10 Double Nickase Plasmid (h) - sc-407658-NIC from Santa Cruz Biotechnology
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Med10 Double Nickase Plasmid (h2) - sc-407658-NIC-2 from Santa Cruz Biotechnology
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Med10 CRISPR Activation Plasmid (h) - sc-407658-ACT from Santa Cruz Biotechnology
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Med10 CRISPR Activation Plasmid (h2) - sc-407658-ACT-2 from Santa Cruz Biotechnology
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Med10 Lentiviral Activation Particles (h) - sc-407658-LAC from Santa Cruz Biotechnology
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Med10 Lentiviral Activation Particles (h2) - sc-407658-LAC-2 from Santa Cruz Biotechnology
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Med10 siRNA (h) - sc-91760 from Santa Cruz Biotechnology
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Med10 shRNA Plasmid (h) - sc-91760-SH from Santa Cruz Biotechnology
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Med10 shRNA (h) Lentiviral Particles - sc-91760-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU034741 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13158 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13158 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05618 from Sigma-Aldrich
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MED10 siRNA (Human) - CRJ3374 from Cohesion Biosciences
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shRNA set against Human MED10 (NM_032286.2) - SHH339835 from Creative biogene
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shRNA set against Human MED10(NM_032286.2) - SHH183305 from Creative biogene
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Human MED10 siRNA - orb273875 from Biorbyt
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MED10 shRNA Plasmid (Human) - CHJ3374 from Cohesion Biosciences
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MED10 miRNA 3'UTR clone - MiUTR1H-06186 from Creative biogene
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