| Gene Symbol | DPYD |
|---|---|
| Entrez Gene | 1806 |
| Alt Symbol | DHP, DHPDHASE, DPD |
| Species | Human |
| Gene Type | protein-coding |
| Description | dihydropyrimidine dehydrogenase |
| Other Description | dihydropyrimidine dehydrogenase [NADP(+)]|dihydrothymine dehydrogenase|dihydrouracil dehydrogenase |
| Swissprots | Q96TH1 Q16761 A8K5A2 Q16694 E9PFN1 Q32NB0 A2RRQ3 B1AN21 Q96HL6 Q12882 A8MWG9 A2RRQ2 |
| Accessions | AAB07049 BAD35129 CAA64973 EAW73002 EAW73003 Q12882 AB003063 BAA89789 AI124948 AK291217 BAF83906 AK297515 BAG59923 BC008379 AAH08379 BC064027 AAH64027 BC108742 AAI08743 BC131777 AAI31778 BC131778 AAI31779 BT006740 AAP35386 DA721123 U09178 AAA57474 U20938 AAB51366 XM_005270562 XP_005270619 XM_006710397 XP_006710460 NM_000110 NP_000101 NM_001160301 NP_001153773 |
| Function | Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells. |
| Top Pathways | Drug metabolism - other enzymes, Pyrimidine metabolism, beta-Alanine metabolism, Pantothenate and CoA biosynthesis |