DPYD

Gene Symbol	DPYD
Entrez Gene	1806
Alt Symbol	DHP, DHPDHASE, DPD
Species	Human
Gene Type	protein-coding
Description	dihydropyrimidine dehydrogenase
Other Description	dihydropyrimidine dehydrogenase [NADP(+)]|dihydrothymine dehydrogenase|dihydrouracil dehydrogenase
Swissprots	Q96TH1 Q16761 A8K5A2 Q16694 E9PFN1 Q32NB0 A2RRQ3 B1AN21 Q96HL6 Q12882 A8MWG9 A2RRQ2
Accessions	AAB07049 BAD35129 CAA64973 EAW73002 EAW73003 Q12882 AB003063 BAA89789 AI124948 AK291217 BAF83906 AK297515 BAG59923 BC008379 AAH08379 BC064027 AAH64027 BC108742 AAI08743 BC131777 AAI31778 BC131778 AAI31779 BT006740 AAP35386 DA721123 U09178 AAA57474 U20938 AAB51366 XM_005270562 XP_005270619 XM_006710397 XP_006710460 NM_000110 NP_000101 NM_001160301 NP_001153773
Function	Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
Subcellular Location	Cytoplasm.
Tissue Specificity	Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells.
Top Pathways	Drug metabolism - other enzymes, Pyrimidine metabolism, beta-Alanine metabolism, Pantothenate and CoA biosynthesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DPYD CRISPR/Cas9 KO Plasmid (h) - sc-403396 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

DPYD HDR Plasmid (h) - sc-403396-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DPYD Double Nickase Plasmid (h) - sc-403396-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DPYD Double Nickase Plasmid (h2) - sc-403396-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DPYD CRISPR Activation Plasmid (h) - sc-403396-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

DPYD CRISPR Activation Plasmid (h2) - sc-403396-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

DPYD Lentiviral Activation Particles (h) - sc-403396-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DPYD Lentiviral Activation Particles (h2) - sc-403396-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DPYD siRNA (h) - sc-45326 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

DPYD shRNA Plasmid (h) - sc-45326-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

DPYD shRNA (h) Lentiviral Particles - sc-45326-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU060711 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1627 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1627 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08570 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr08570

DPYD siRNA (Human) - CRH1258 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

DPYD RNAi - H00001806-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

DPYD - MBS8213116 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human DPYD (NM_000110.3) - SHH280861 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human DPYD(NM_000110.3) - SHH015167 from Creative biogene Category siRNA Species Reactivities Human

Human DPYD siRNA - orb261760 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

DPYD shRNA Plasmid (Human) - CHH1258 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

DPYD miRNA 3'UTR clone - MiUTR1H-02987 from Creative biogene Species Reactivities Human

DPYD miRNA 3'UTR clone - MiUTR3H-12596 from Creative biogene Species Reactivities Human

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