Gene Symbol | OXCT2 |
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Entrez Gene | 64064 |
Alt Symbol | FKSG25, SCOTT |
Species | Human |
Gene Type | protein-coding |
Description | 3-oxoacid CoA transferase 2 |
Other Description | 3-oxoacid CoA-transferase 2A|3-oxoacid-CoA transferase 2A|succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial|succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial|testis-specific succinyl CoA:3-oxoacid CoA-transferase|testis-specific succinyl-CoA:3-oxoacid CoA-transferase |
Swissprots | Q9H1I4 Q5QPK4 Q8NHR1 Q9BYC2 B2RBB4 |
Accessions | CBH19406 Q9BYC2 AB050193 BAB40810 AK024440 BAB15730 AK093089 BAG52651 AK314586 BAG37161 AY013700 AAG33922 BC030015 BC072388 AAH72388 DQ893340 ABM84266 DQ896660 ABM87659 NM_022120 NP_071403 |
Function | Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). {ECO:0000250}. |
Subcellular Location | Mitochondrion {ECO:0000269|PubMed:11756565}. |
Tissue Specificity | Testis specific. {ECO:0000269|PubMed:11756565}. |
Top Pathways | Synthesis and degradation of ketone bodies, Valine, leucine and isoleucine degradation, Butanoate metabolism |
SCOT-t CRISPR/Cas9 KO Plasmid (h) - sc-408534 from Santa Cruz Biotechnology
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SCOT-t HDR Plasmid (h) - sc-408534-HDR from Santa Cruz Biotechnology
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SCOT-t Double Nickase Plasmid (h) - sc-408534-NIC from Santa Cruz Biotechnology
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SCOT-t Double Nickase Plasmid (h2) - sc-408534-NIC-2 from Santa Cruz Biotechnology
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SCOT-t CRISPR Activation Plasmid (h) - sc-408534-ACT from Santa Cruz Biotechnology
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SCOT-t CRISPR Activation Plasmid (h2) - sc-408534-ACT-2 from Santa Cruz Biotechnology
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SCOT-t Lentiviral Activation Particles (h) - sc-408534-LAC from Santa Cruz Biotechnology
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SCOT-t Lentiviral Activation Particles (h2) - sc-408534-LAC-2 from Santa Cruz Biotechnology
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SCOT-t siRNA (h) - sc-88311 from Santa Cruz Biotechnology
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SCOT-t shRNA Plasmid (h) - sc-88311-SH from Santa Cruz Biotechnology
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SCOT-t shRNA (h) Lentiviral Particles - sc-88311-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU117661 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16215 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16215 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00691 from Sigma-Aldrich
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OXCT2 siRNA (Human) - CRJ1897 from Cohesion Biosciences
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shRNA set against Human OXCT2(NM_022120.1) - SHR084264 from Creative biogene
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Human OXCT2 siRNA - orb272398 from Biorbyt
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OXCT2 shRNA Plasmid (Human) - CHJ1897 from Cohesion Biosciences
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OXCT2 miRNA 3'UTR clone - MiUTR1H-07426 from Creative biogene
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