CEBPA

Gene Symbol CEBPA
Entrez Gene 1050
Alt Symbol C/EBP-alpha, CEBP
Species Human
Gene Type protein-coding
Description CCAAT/enhancer binding protein (C/EBP), alpha
Other Description CCAAT/enhancer-binding protein alpha
Swissprots P78319 P49715 Q05CA4 A7LNP2
Accessions AAC50235 ABS82765 P49715 BC027902 AAH27902 BC063874 AAH63874 BC160133 AAI60133 X87248 CAA60698 Y11525 CAA72289 NM_001285829 NP_001272758 NM_001287424 NP_001274353 NM_001287435 NP_001274364 NM_004364 NP_004355
Function Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes (PubMed:11242107). During early embryogenesis, plays essential and redundant functions with CEBPB. Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP). Critical for the proper development of the liver and the lung (By similarity). Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage (By similarity). To regulate these different processes at the proper moment and tissue, interplays with other transcription factors and modulators. Downregulates the expression of genes that maintain cells in an undifferentiated and proliferative state through E2F1 repression, which is c
Subcellular Location Nucleus {ECO:0000269|PubMed:11242107}.
Top Pathways Acute myeloid leukemia, Non-alcoholic fatty liver disease (NAFLD), Transcriptional misregulation in cancer

Phospho-C/EBPα (Ser21) Antibody - 2841 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of COS cells untransfected (lane 1), or transfected with wild-type mouse C/EBPalpha (lane 2), S21A (lane 3), and S21D (lane 4) mutants, using Phospho-C/EBPalpha (Ser21) Antibody (upper) or C/EBPalpha Antibody (lower). (Provided by Dr. Hanna Radomska, Beth Israel Deaconess Medical Center, Boston, MA).

Phospho-C/EBPα (Thr222/226) Antibody - 2844 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from U937 cells treated with either LiCl or NaCl for the indicated times, using Phopho-C/EBPalpha (Thr222/226) Antibody (upper) and C/EBPalpha antibody (lower). C/EBPalpha phosphorylation at Thr222/226 is abolished by the specific GSK3 inhibitor LiCl, but not by NaCl, indicating that phosphorylation at these sites are depends on GSK3 kinase.

C/EBPα (D56F10) XP ® Rabbit mAb - 8178 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D56F10
Western blot analysis of extracts from Hep G2 and LNCaP cells using C/EBPα (D56F10) XP ® Rabbit mAb.

C/EBPalpha (p42) Antibody - 2843 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from U937 cells, using C/EBPalpha (p42) Antibody.

C/EBPα Antibody - 2295 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from THP1 and NIH/3T3-L1 cells using C/EBPα Antibody.

C/EBP α (D-5) - sc-365318 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
C/EBP α (D-5): sc-365318. Western blot analysis of C/EBP α expression in Caki-1 (A) and HeLa (B) whole cell lysates.

C/EBP α (C-18) - sc-9314 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
C/EBP α (C-18): sc-9314. Western blot analysis of C/EBP α expression in rat liver (A) and mouse liver (B) tissue extracts.

C/EBP α (G-10) - sc-166258 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
C/EBP α (G-10): sc-166258. Western blot analysis of C/EBP α expression in non-transfected: sc-117752 (A) and mouse C/EBP α transfected: sc-126523 (B) 293T whole cell lysates.

C/EBP α (14AA) - sc-61 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
C/EBP α (14AA): sc-61. Western blot analysis of C/EBP α expression in rat liver tissue extract.

C/EBP α (K-19) - sc-21820 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

C/EBP α (N-19) - sc-9315 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
C/EBP α (N-19): sc-9315. Western blot analysis of C/EBP α expression in non-transfected 293T: sc-117752 (A), mouse C/EBP α transfected: sc-126523 (B) 293T whole cell lysates.

Anti-CEBP Alpha (phospho S21) antibody - ab52193 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using ab52193 at a 1/50 dilution.Left image un-treated.Right image treated with phosphopeptide.

Anti-CEBP Alpha (phospho T226) antibody - ab63543 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CEBP Alpha (phospho T226) antibody (ab63543) at 1/500 dilutionLane 1 : Extracts from COS7 cells, treated with EGF (200ng/ml, 30mins)Lane 2 : Extracts from COS7 cells, treated with EGF (200ng/ml, 30mins), with immunizing phosphopeptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-CEBP Alpha (phospho T230) antibody - ab194531 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CEBP Alpha (phospho T230) antibody (ab194531) at 1/500 dilutionLane 1 : COS7 cell extract with antigen-specific peptideLane 2 : COS7 cell extract

Anti-CEBP Alpha antibody - ab15048 from Abcam

Prices $388.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
developed using the ECL techniquePerformed under non-reducing conditions.

Anti-CEBP Alpha antibody - ab63486 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
This image shows human lung carcinoma tissue stained with ab63486 at 1/50 dilution; with and without the immunising peptide.

Anti-CEBP Alpha antibody - ab102773 from Abcam

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CEBP Alpha antibody (ab102773) at 1/100 dilution + Mouse liver tissue lysate at 35 µg

Anti-CEBP Alpha antibody - ab62652 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of HeLa cells, using ab62652 at a 1/500 dilution. Left image untreated. Right image treated with peptide.

Anti-CEBP Alpha antibody - ab63640 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CEBP Alpha antibody (ab63640) at 1/500 dilutionLane 1 : extracts from COS7 cell extracts treated with EGF (200ng/ml, 30mins)Lane 2 : extracts from COS7 cell extracts treated with EGF (200ng/ml, 30mins) with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-CEBP Alpha antibody [4E10] - ab128162 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4E10
Example of standard curve obtained with ab128162

Anti-CEBP Alpha antibody [5B7] - ab128482 from Abcam

Prices $387.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5B7
ab128482, at a 1/200 dilution, staining CEBP Alpha in HeLa cells by Immunofluorescence. Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.

Anti-CEBP Alpha antibody [EP708Y] - ab40761 from Abcam

Prices $394.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP708Y
Anti-CEBP Alpha antibody [EP708Y] (ab40761) at 1/1000 dilution + U937 + LPS cell lysate at 10 µg

Anti-CEBP Alpha antibody [EP709Y] - ab40764 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP709Y
Anti-CEBP Alpha antibody [EP709Y] (ab40764) at 1/20000 dilution + U937 cell lysate at 10 µg

Anti-C/EBP Alpha / CEBPA Antibody (aa342-358) - LS-C312618 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
C/EBP Alpha / CEBPA antibody. IHC(P): Human Breast Cancer Tissue.

Anti-C/EBP Alpha / CEBPA Antibody (aa288-337) IHC-plus™ - LS-B4685 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CEBPA / CEBP Alpha antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4685 concentration 5 ug/ml.
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