| Gene Symbol |
LRR1
|
| Entrez Gene |
122769
|
| Alt Symbol |
4-1BBLRR, LRR-1, PPIL5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
leucine rich repeat protein 1
|
| Other Description |
4-1BB-mediated signaling molecule|4-1BB-mediated-signaling molecule|LRR-repeat protein 1|cyclophilin-like 5|leucine-rich repeat protein 1|peptidylprolyl isomerase (cyclophilin)-like 5|peptidylprolyl isomerase-like 5
|
| Swissprots |
Q52M24 Q86SZ1 B4DDE0 Q96L50 Q8N6H9 A5D6X3
|
| Accessions |
EAW65761 EAW65762 EAW65763 EAW65764 Q96L50 AA742244 AK293156 BAG56701 AY052405 AAL11430 BC030142 AAH30142 BC064133 AAH64133 BC093697 AAH93697 BC107888 AAI07889 BC112241 AAI12242 BC139921 AAI39922 BC146425 AAI46426 BC148859 AAI48860 BI825814 BI826606 BI829295 BQ059807 BX248298 CAD62625 BX648029 CAH10374 DQ892269 ABM83195 DQ895470 ABM86396 NM_152329 NP_689542 NM_203467 NP_982292 NR_037792 NR_037793 NM_203466
|
| Function |
May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. Probable substrate recognition subunit of an ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269|PubMed:15601820}.
|
| Tissue Specificity |
Ubiquitous. Maximal expression was seen in the heart and skeletal muscle and minimal expression seen in the kidney.
|