Gene Symbol | PRPF40A |
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Entrez Gene | 55660 |
Alt Symbol | FBP-11, FBP11, FLAF1, FNBP3, HIP-10, HIP10, HYPA, NY-REN-6, Prp40 |
Species | Human |
Gene Type | protein-coding |
Description | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) |
Other Description | Fas-ligand associated factor 1|Huntingtin-interacting protein A|NY-REN-6 antigen|fas ligand-associated factor 1|formin binding protein 3|formin-binding protein 11|huntingtin yeast partner A|huntingtin-interacting protein 10|pre-mRNA-processing factor 40 homolog A|renal carcinoma antigen NY-REN-6 |
Swissprots | O75400 Q9P0Q2 Q9NWU9 O43856 Q9Y5A8 Q8TBQ1 O75404 Q9H782 |
Accessions | AAX88960 EAX11482 O75400 AF049523 AAC27501 AF049524 AAC27502 AF049528 AAC27506 AF151059 AAF36145 AF155096 AAD42862 AK000592 BAA91277 AK021621 AK024810 BAB15016 AK298547 BAG60744 AK315187 BAG37627 BC000273 BC011788 AAH11788 BC027178 AAH27178 BC029414 AAH29414 BC073138 BU753487 EG328171 U70667 AAB93495 XM_005246676 XP_005246733 XM_005246677 XP_005246734 XM_005246678 XP_005246735 XM_011511446 XP_011509748 XM_011511447 XP_011509749 XM_011511448 XP_011509750 XM_011511449 XP_011509751 NM_017892 NP_060362 |
Function | Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
Subcellular Location | Nucleus speckle {ECO:0000250}. Nucleus matrix {ECO:0000269|PubMed:16391387}. Note=Colocalizes with AKAP8L in the nuclear matrix. {ECO:0000250}. |
Tissue Specificity | Expressed in the brain cortex (at protein level). Widely expressed. {ECO:0000269|PubMed:16391387, ECO:0000269|PubMed:9700202}. |
Top Pathways | Spliceosome |
FNBP3 CRISPR/Cas9 KO Plasmid (h) - sc-412568 from Santa Cruz Biotechnology
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FNBP3 HDR Plasmid (h) - sc-412568-HDR from Santa Cruz Biotechnology
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FNBP3 Double Nickase Plasmid (h) - sc-412568-NIC from Santa Cruz Biotechnology
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FNBP3 Double Nickase Plasmid (h2) - sc-412568-NIC-2 from Santa Cruz Biotechnology
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FNBP3 CRISPR Activation Plasmid (h) - sc-412568-ACT from Santa Cruz Biotechnology
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FNBP3 CRISPR Activation Plasmid (h2) - sc-412568-ACT-2 from Santa Cruz Biotechnology
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FNBP3 Lentiviral Activation Particles (h) - sc-412568-LAC from Santa Cruz Biotechnology
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FNBP3 Lentiviral Activation Particles (h2) - sc-412568-LAC-2 from Santa Cruz Biotechnology
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FNBP3 siRNA (h) - sc-62331 from Santa Cruz Biotechnology
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FNBP3 shRNA Plasmid (h) - sc-62331-SH from Santa Cruz Biotechnology
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FNBP3 shRNA (h) Lentiviral Particles - sc-62331-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU082041 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17478 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17478 from Sigma-Aldrich
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PRPF40A siRNA (Human) - CRJ0812 from Cohesion Biosciences
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shRNA set against Human PRPF40A (NM_017892.3) - SHH383788 from Creative biogene
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shRNA set against Human PRPF40A(NM_017892.3) - SHR143130 from Creative biogene
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Human PRPF40A siRNA - orb271313 from Biorbyt
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PRPF40A shRNA Plasmid (Human) - CHJ0812 from Cohesion Biosciences
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PRPF40A miRNA 3'UTR clone - MiUTR1H-08317 from Creative biogene
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