| Gene Symbol |
KRT14
|
| Entrez Gene |
3861
|
| Alt Symbol |
CK14, EBS3, EBS4, K14, NFJ
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
keratin 14, type I
|
| Other Description |
CK-14|cytokeratin 14|cytokeratin-14|keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner)|keratin, type I cytoskeletal 14|keratin-14
|
| Swissprots |
Q14715 Q9BUE3 P02533 Q9UBN2 Q9UBN3 Q9UCY4 Q53XY3
|
| Accessions |
AAB59562 AAF04034 AAF04035 AAF04036 AAF04037 AAF04038 AAF04039 EAW60745 EAW60746 EAW60747 EAW60748 P02533 AK309280 BC002690 AAH02690 BC019097 AAH19097 BC042437 AAH42437 BC094830 AAH94830 BT007186 AAP35850 DB018715 DQ890733 ABM81659 DQ892997 ABM83923 DQ893905 ABM84831 M28646 AAA96689 NM_000526 NP_000517
|
| Function |
The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. {ECO:0000269|PubMed:11724817}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Expressed in both as a filamentous pattern.
|
| Tissue Specificity |
Detected in the basal layer, lowered within the more apically located layers specifically in the stratum spinosum, stratum granulosum but is not detected in stratum corneum. Strongly expressed in the outer root sheath of anagen follicles but not in the germinative matrix, inner root sheath or hair. Found in keratinocytes surrounding the club hair during telogen. {ECO:0000269|PubMed:9457912}.
|
![Western Blot: Cytokeratin 14 Overexpression Lysate (Adult Normal) [NBL1-12381] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Cytokeratin 14.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9256_Cytokeratin%252014%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12381-img0002.jpg)