Gene Symbol | GHSR |
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Entrez Gene | 2693 |
Alt Symbol | GHDP |
Species | Human |
Gene Type | protein-coding |
Description | growth hormone secretagogue receptor |
Other Description | GH-releasing peptide receptor|GHRP|GHS-R|ghrelin receptor|growth hormone secretagogue receptor type 1 |
Swissprots | Q14D12 Q92847 Q96RJ7 Q92848 Q6ISR8 |
Accessions | AAC97506 AAK71539 AAK71540 AAP84357 ABN09829 CAJ34548 CAS01830 CCD32722 EAW78468 EAW78469 Q92847 AY429112 AAR07907 BC069068 AAH69068 BC069374 AAH69374 BC113547 AAI13548 HQ258211 ADR82965 U60179 AAC50653 U60181 AAC50654 NM_004122 NP_004113 NM_198407 NP_940799 |
Function | Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine). {ECO:0000269|PubMed:10604470, ECO:0000269|PubMed:11322507}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Pituitary and hypothalamus. |
Top Pathways | cAMP signaling pathway, Neuroactive ligand-receptor interaction |
GHS-R1 CRISPR/Cas9 KO Plasmid (h) - sc-401724 from Santa Cruz Biotechnology
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GHS-R1 HDR Plasmid (h) - sc-401724-HDR from Santa Cruz Biotechnology
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GHS-R1 Double Nickase Plasmid (h) - sc-401724-NIC from Santa Cruz Biotechnology
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GHS-R1 Double Nickase Plasmid (h2) - sc-401724-NIC-2 from Santa Cruz Biotechnology
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GHS-R1 CRISPR Activation Plasmid (h) - sc-401724-ACT from Santa Cruz Biotechnology
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GHS-R1 CRISPR Activation Plasmid (h2) - sc-401724-ACT-2 from Santa Cruz Biotechnology
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GHS-R1 Lentiviral Activation Particles (h) - sc-401724-LAC from Santa Cruz Biotechnology
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GHS-R1 Lentiviral Activation Particles (h2) - sc-401724-LAC-2 from Santa Cruz Biotechnology
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GHS-R1 siRNA (h) - sc-40017 from Santa Cruz Biotechnology
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GHS-R shRNA Plasmid (h) - sc-40017-SH from Santa Cruz Biotechnology
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GHS-R shRNA (h) Lentiviral Particles - sc-40017-V from Santa Cruz Biotechnology
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Ghrelin Receptor/GHSR RNAi - H00002693-R03 from Novus Biologicals
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MISSION® esiRNA - EHU136891 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2573 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2573 from Sigma-Aldrich
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GHSR siRNA (Human) - CRH1796 from Cohesion Biosciences
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Ghrelin Receptor/GHSR RNAi - H00002693-R04 from Novus Biologicals
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GHSR - MBS8205753 from MyBioSource
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shRNA set against Human Gh (NM_004122.2) - SHH300926 from Creative biogene
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GHSR shRNA Plasmid (Human) - CHH1796 from Cohesion Biosciences
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GHSR miRNA 3'UTR clone - MiUTR4H-TG11303 from Creative biogene
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