Hpse

Gene Symbol	Hpse
Entrez Gene	15442
Alt Symbol	HSE1, Hpa, Hpr1
Species	Mouse
Gene Type	protein-coding
Description	heparanase
Other Description	endo-glucoronidase|endoglycosidase heparanase
Swissprots	B2RS99 Q8K3K3 Q6YGZ1
Accessions	ABG57024 EDL20281 EDL20282 EDL20283 Q6YGZ1 AF359507 AAQ15188 AK040471 BAC30600 AK087283 AK154628 BAE32725 AK190307 AK197417 AK197785 AK200041 AY077467 AAL76083 AY151051 AAN41636 BC099521 BC138782 AAI38783 BC138784 AAI38785 NM_152803 NP_690016
Function	Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation fa
Subcellular Location	Lysosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Secreted {ECO:0000269|PubMed:15793281}. Nucleus {ECO:0000269|PubMed:15793281}. Note=Proheparanase is secreted via vesicles of the Golgi. Interacts with cell membrane heparan sulfate proteoglycans (HSPGs). Endocytosed and accumulates in endosomes. Transferred to lysosomes where it is proteolytically cleaved to produce the active enzyme. Under certain stimuli, transferred to the cell surface. Colocalizes with SDC1 in endosomal/lysosomal vesicles. Accumulates in perinuclear lysosomal vesicles. Heparin retains proheparanase in the extracellular medium (By similarity). Associates with lipid rafts. {ECO:0000250}.
Tissue Specificity	Expressed in skin, mainly in the stratum granulosum and the first layer of the stratum corneum in the upper part of the epidermis. Also detected in hair follicles and in sebaceous glands. {ECO:0000269|PubMed:15793281, ECO:0000269|PubMed:18589009}.
Top Pathways	Proteoglycans in cancer, Glycosaminoglycan degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Heparanase (HPA), Mouse, ELISA Kit - SEA711Mu from ARP American Research Products Category ELISA Kit Prices $668.00 Sizes 96 t Sensitivity 6.5pg/mL Range 15.6-1,000pg/mL

Heparanase (HPSE), Mouse, ELISA Kit - CSB-EL010716MO from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Heparanase, Hpse, Mouse, ELISA Kit - E0711m from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 78-5000 pg/mL

Heparanase, Mouse, ELISA Kit - E03H0100 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 1.0 pg/mL, Range 250-5000pg/mL,

Mouse HPA ELISA Kit - MH0107 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Mouse HPA(Heparanase) ELISA Kit - E-EL-M0655 from Elabscience Category ELISA Kit Sensitivity 46.88 pg/mL Range 78.13—5000 pg/mL

Mouse HPA (Heparanase) CLIA Kit - E-CL-M0404 from Elabscience Category CLIA Kit Sensitivity 9.38 pg/mL Range Average Recovery (%)

heparanase, ELISA Kit - MBS906653 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of mouse HPSE is typically less than 7.8 mU/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 31.25 mU/ml -2000 mU/ml.

Mouse Heparanase(HPSE) ELISA kit - CSB-EL010716MO from Cusabio Category ELISA Kit Sensitivity 7.8 mU/ml Range 31.25 mU/ml-2000 mU/ml

Mouse Heparanase ELISA - E03H0100 from BlueGene Biotech Category ELISA Kit

ELISA Kit for Heparanase (HPA) - SEA711Mu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 6.7pg/mL. Range 15.625-1000pg/mL The standard curve concentrations used for the ELISA's were 1000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL, 31.25pg/mL, 15.625pg/mL

Mouse Heparanase (HPA) ELISA Kit - EKU04738 from Biomatik Category ELISA Kit Prices $680.00, $3,028.00, $5,511.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 6.5 pg/mL Range 15.6-1000 pg/mL

Mouse HPA(Heparanase) ELISA Kit - E-EL-M0655 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 46.88 pg/mL Range 78.13~5000 pg/mL

Mouse HPA (Heparanase) CLIA Kit - E-CL-M0404 from Iwai North America Inc. Category CLIA Kit Prices $722.50 Sizes 1 kit Sensitivity 46.875pg/mL Range 78.125-5000pg/mL

Mouse Heparanase ELISA Kit - abx154132 from Abbexa Category ELISA Kit Range 15.63 pg/ml - 1000 pg/ml

Mouse Heparanase ELISA Kit - abx254800 from Abbexa Category ELISA Kit Range 78.125 pg/ml - 5000 pg/ml

Heparanase (HPA), Mouse, ELISA Kit - DL-HPA-Mu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Range 15.6-1,000 pg/mL

Mouse Heparanase (HPSE) ELISA Kit - EKC37037 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 7.8 mU/ml Range 31.25 mU/ml-2000 mU/ml

Mouse Heparanase ELISA Kit - EKE51807 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Range 78-5000 pg/mL

HPA/Hpse - EKM892 from Nordic BioSite Sensitivity 46.875pg/ml Range 78.125-5000pg/ml

HPA/Hpse - EKM0892 from Nordic BioSite Sensitivity 46.875pg/ml Range 78.125-5000pg/ml

Mouse HPA ELISA Kit - E055491 from Biobool Category ELISA Kit Sensitivity 1.0 pg/mL.

Mouse HPA/Hpse ELISA Kit - E055493 from Biobool Category ELISA Kit Sensitivity <46.9pg/ml

Mouse Hpse ELISA Kit - E055494 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of mouse HPSE is typically less than 7.8 mU/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean

HPSE ELISA Kit (Mouse) (OKEH03201) - OKEH03201 from Aviva Systems Biology Category ELISA Kit Prices $425.00 Sizes 96 wells Sensitivity 39 pg/mL Range 78 - 5,000 pg/mL

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