Hpse

Gene Symbol	Hpse
Entrez Gene	15442
Alt Symbol	HSE1, Hpa, Hpr1
Species	Mouse
Gene Type	protein-coding
Description	heparanase
Other Description	endo-glucoronidase|endoglycosidase heparanase
Swissprots	B2RS99 Q8K3K3 Q6YGZ1
Accessions	ABG57024 EDL20281 EDL20282 EDL20283 Q6YGZ1 AF359507 AAQ15188 AK040471 BAC30600 AK087283 AK154628 BAE32725 AK190307 AK197417 AK197785 AK200041 AY077467 AAL76083 AY151051 AAN41636 BC099521 BC138782 AAI38783 BC138784 AAI38785 NM_152803 NP_690016
Function	Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation fa
Subcellular Location	Lysosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Secreted {ECO:0000269|PubMed:15793281}. Nucleus {ECO:0000269|PubMed:15793281}. Note=Proheparanase is secreted via vesicles of the Golgi. Interacts with cell membrane heparan sulfate proteoglycans (HSPGs). Endocytosed and accumulates in endosomes. Transferred to lysosomes where it is proteolytically cleaved to produce the active enzyme. Under certain stimuli, transferred to the cell surface. Colocalizes with SDC1 in endosomal/lysosomal vesicles. Accumulates in perinuclear lysosomal vesicles. Heparin retains proheparanase in the extracellular medium (By similarity). Associates with lipid rafts. {ECO:0000250}.
Tissue Specificity	Expressed in skin, mainly in the stratum granulosum and the first layer of the stratum corneum in the upper part of the epidermis. Also detected in hair follicles and in sebaceous glands. {ECO:0000269|PubMed:15793281, ECO:0000269|PubMed:18589009}.
Top Pathways	Proteoglycans in cancer, Glycosaminoglycan degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Mouse Heparanase Protein - abx067059 from Abbexa Category Protein Source E.coli Species Mouse

Mouse Heparanase Protein - abx067058 from Abbexa Category Protein Source E.coli Species Mouse

Mouse Heparanase Protein - abx067056 from Abbexa Category Protein Source E.coli Species Mouse

Heparanase (HPA), Mouse - 20-7025 from ARP American Research Products Category Protein Prices $429.00 Sizes 50 µg Source E.coli Species Mouse

Heparanase (HPA), Mouse - 20-7026 from ARP American Research Products Category Protein Prices $429.00 Sizes 50 µg Source E.coli Species Mouse

Heparanase (HPA), Mouse - 20-7027 from ARP American Research Products Category Protein Prices $429.00 Sizes 50 µg Source E.coli Species Mouse

Recombinant Heparanase (HPA) - RPA711Mu01 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant Heparanase (HPA) - RPA711Mu02 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant Heparanase (HPA) - RPA711Mu03 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant Heparanase (HPA) - RPA711Mu04 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant Mouse Heparanase(Hpse) - CSB-YP010716MO CSB-EP010716MO CSB-BP010716MO CSB-MP010716MO from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Mouse

Heparanase (HPA) - RPU141867 from Biomatik Category Protein Prices $198.00, $396.00, $594.00 Sizes 10 µg, 50 µg, 100 µg Source E.coli Species Mouse

Heparanase (HPA) - RPU141869 from Biomatik Category Protein Prices $198.00, $396.00, $594.00 Sizes 10 µg, 50 µg, 100 µg Source E.coli Species Mouse

Heparanase (HPA) - RPU141870 from Biomatik Category Protein Prices $198.00, $396.00, $594.00 Sizes 10 µg, 50 µg, 100 µg Source E.coli Species Mouse

Heparanase Protein (Recombinant) - abx167193 from Abbexa Category Protein Source Mouse Species Mouse

Recombinant Mouse HPSE Protein - HPSE-7838M from Creative Biomart Category Protein Source Mammalian Cells Species Mouse

Recombinant Heparanase (HPA) - RPU41867 from Biomatik Category Protein Prices $187.00, $324.00, $495.00, $619.20 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Mouse

Recombinant Heparanase (HPA) - RPU41869 from Biomatik Category Protein Prices $187.00, $324.00, $495.00, $619.20 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Mouse

Recombinant Heparanase (HPA) - RPU41870 from Biomatik Category Protein Prices $187.00, $324.00, $495.00, $619.20 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Mouse

Recombinant Heparanase (HPA) - RPU50978 from Biomatik Category Protein Prices $187.00, $324.00, $495.00, $619.20 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Mouse

HPSE Recombinant Protein (OPCD03948) - OPCD03948 from Aviva Systems Biology Category Protein Source E.coli Species Mouse

HPSE Recombinant Protein (OPCD03950) - OPCD03950 from Aviva Systems Biology Category Protein Source E.coli Species Mouse

HPSE Recombinant Protein (OPCD03952) - OPCD03952 from Aviva Systems Biology Category Protein Source E.coli Species Mouse

HPSE Recombinant Protein (OPCD03955) - OPCD03955 from Aviva Systems Biology Category Protein Source E.coli Species Mouse

Heparanase (HPA), Recombinant Protein - MBS2010397 from MyBioSource Category Protein Prices $165.00, $325.00, $505.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Mouse

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