| Gene Symbol |
ANAPC13
|
| Entrez Gene |
25847
|
| Alt Symbol |
APC13, SWM1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
anaphase promoting complex subunit 13
|
| Other Description |
anaphase-promoting complex subunit 13|cyclosome subunit 13
|
| Swissprots |
Q9BS18 Q9Y3V0
|
| Accessions |
EAW79143 EAW79144 EAW79145 EAW79146 EAW79147 EAW79148 EAW79149 Q9BS18 AF086169 AK001285 AK026550 AK290761 BAF83450 AL050051 CAB43251 AV682398 BC005398 AAH05398 BG428689 BU627217 BU852706 BX537696 CN258858 NM_001242374 NP_001229303 NM_001242375 NP_001229304 NM_015391 NP_056206
|
| Function |
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:15060174, ECO:0000269|PubMed:18485873}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Top Pathways |
Cell cycle, Ubiquitin mediated proteolysis, Progesterone-mediated oocyte maturation, Oocyte meiosis
|
![Western Blot: ANAPC13 Overexpression Lysate (Adult Normal) [NBL1-07515] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ANAPC13.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3846_ANAPC13%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-07515-img0002.jpg)