| Gene Symbol |
CCND1
|
| Entrez Gene |
595
|
| Alt Symbol |
BCL1, D11S287E, PRAD1, U21B31
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cyclin D1
|
| Other Description |
B-cell CLL/lymphoma 1|B-cell lymphoma 1 protein|BCL-1 oncogene|G1/S-specific cyclin-D1|PRAD1 oncogene
|
| Swissprots |
Q6LEF0 P24385
|
| Accessions |
AAA36481 AAM34300 CAA82318 CDI30198 EAW74746 EAW74747 EAW74748 P24385 AB075505 AK299044 BAG61118 AK313136 BAG35955 AM393193 CAL38071 AM393430 CAL38308 AM393593 CAL38470 AY830112 AAV91344 BC000076 AAH00076 BC001501 AAH01501 BC014078 AAH14078 BC023620 AAH23620 BC025302 AAH25302 BM796500 BT019844 AAV38647 BT019845 AAV38648 CR536538 CAG38775 CR542099 CAG46896 DQ891848 ABM82774 DQ895038 ABM85964 M64349 AAA52136 M73554 AAA58392 M74092 S71637 X59798 CAA42470 XM_006718653 XP_006718716 NM_053056 NP_444284
|
| Function |
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner. {ECO:0000269|PubMed:15241418, ECO:0000269|PubMe
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:9106657}. Cytoplasm {ECO:0000269|PubMed:9106657}. Membrane {ECO:0000269|PubMed:9106657}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members. {ECO:0000250}.
|
| Top Pathways |
MicroRNAs in cancer, Wnt signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Oxytocin signaling pathway
|
![Western Blot: Cyclin D1 Overexpression Lysate (Denatured) [H00000595-T01] - Lane 1: CCND1 transfected lysate (32.56 KDa). Lane 2: Non-transfected lysate.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/27852_Cyclin-D1-Overexpression-Lysate-(Denatured)-Western-Blot-H00000595-T01-img0002.jpg)
![Western Blot: Cyclin D1 Overexpression Lysate (Adult Normal) [NBL1-08871] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Cyclin D1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6123_Cyclin%2520D1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-08871-img0002.jpg)