CCND1

Gene Symbol	CCND1
Entrez Gene	595
Alt Symbol	BCL1, D11S287E, PRAD1, U21B31
Species	Human
Gene Type	protein-coding
Description	cyclin D1
Other Description	B-cell CLL/lymphoma 1|B-cell lymphoma 1 protein|BCL-1 oncogene|G1/S-specific cyclin-D1|PRAD1 oncogene
Swissprots	Q6LEF0 P24385
Accessions	AAA36481 AAM34300 CAA82318 CDI30198 EAW74746 EAW74747 EAW74748 P24385 AB075505 AK299044 BAG61118 AK313136 BAG35955 AM393193 CAL38071 AM393430 CAL38308 AM393593 CAL38470 AY830112 AAV91344 BC000076 AAH00076 BC001501 AAH01501 BC014078 AAH14078 BC023620 AAH23620 BC025302 AAH25302 BM796500 BT019844 AAV38647 BT019845 AAV38648 CR536538 CAG38775 CR542099 CAG46896 DQ891848 ABM82774 DQ895038 ABM85964 M64349 AAA52136 M73554 AAA58392 M74092 S71637 X59798 CAA42470 XM_006718653 XP_006718716 NM_053056 NP_444284
Function	Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner. {ECO:0000269|PubMed:15241418, ECO:0000269|PubMe
Subcellular Location	Nucleus {ECO:0000269|PubMed:9106657}. Cytoplasm {ECO:0000269|PubMed:9106657}. Membrane {ECO:0000269|PubMed:9106657}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members. {ECO:0000250}.
Top Pathways	MicroRNAs in cancer, Wnt signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Oxytocin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® Cyclin D1 siRNA I - 12962 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® Cyclin D1 siRNA II - 13015 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

cyclin D1 CRISPR/Cas9 KO Plasmid (h) - sc-400047 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

cyclin D1 HDR Plasmid (h) - sc-400047-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

cyclin D1 Double Nickase Plasmid (h) - sc-400047-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

cyclin D1 Double Nickase Plasmid (h2) - sc-400047-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

cyclin D1 CRISPR Activation Plasmid (h) - sc-400047-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

cyclin D1 CRISPR Activation Plasmid (h2) - sc-400047-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

cyclin D1 Lentiviral Activation Particles (h) - sc-400047-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

cyclin D1 Lentiviral Activation Particles (h2) - sc-400047-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

cyclin D1 siRNA (h) - sc-29286 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

cyclin D1 shRNA Plasmid (h) - sc-29286-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

cyclin D1 shRNA (h) Lentiviral Particles - sc-29286-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

cyclin D1 siRNA (h2) - sc-44257 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

cyclin D1 shRNA Plasmid (h2) - sc-44257-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

cyclin D1 shRNA (h2) Lentiviral Particles - sc-44257-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Cyclin D1 RNAi - H00000595-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU153321 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1442 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit - CKOZFN1443 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit - CKOZFN1444 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1444 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1442 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1443 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR13994 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr13994

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