PTK2B
| Gene Symbol | PTK2B |
|---|---|
| Entrez Gene | 2185 |
| Alt Symbol | CADTK, CAKB, FADK2, FAK2, PKB, PTK, PYK2, RAFTK |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein tyrosine kinase 2 beta |
| Other Description | CAK-beta|FADK 2|PTK2B protein tyrosine kinase 2 beta|calcium-dependent tyrosine kinase|calcium-regulated non-receptor proline-rich tyrosine kinase|cell adhesion kinase beta|focal adhesion kinase 2|proline-rich tyrosine kinase 2|protein kinase B|protein-tyrosine kinase 2-beta|related adhesion focal tyrosine kinase |
| Swissprots | Q6PID4 Q14290 Q13475 Q16709 D3DST0 Q14289 |
| Accessions | EAW63553 EAW63554 EAW63555 EAW63556 Q14289 AB209085 BAD92322 AK128371 BAC87404 AL120380 AW130888 AY429564 BC036651 AAH36651 BC042599 AAH42599 BF796371 BM712234 BQ009032 D45853 BAA08289 DA773624 DQ590775 L49207 AAB47217 U33284 AAC50203 U43522 AAC05330 XM_005273447 XP_005273504 XM_005273448 XP_005273505 XM_011544441 XP_011542743 XM_011544442 XP_011542744 NM_004103 NP_004094 NM_173174 NP_775266 NM_173175 NP_775267 NM_173176 NP_775268 |
| Function | Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T- cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activati |
| Subcellular Location | Cytoplasm. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, focal adhesion. Cell projection, lamellipodium. Cytoplasm, cell cortex. Nucleus. Note=Interaction with NPHP1 induces the membrane-association of the kinase. Colocalizes with integrins at the cell periphery. |
| Tissue Specificity | Most abundant in the brain, with highest levels in amygdala and hippocampus. Low levels in kidney (at protein level). Also expressed in spleen and lymphocytes. {ECO:0000269|PubMed:7544443, ECO:0000269|PubMed:9545257}. |
| Top Pathways | Natural killer cell mediated cytotoxicity, Leukocyte transendothelial migration, GnRH signaling pathway, Calcium signaling pathway, Chemokine signaling pathway |
Mouse/Human/Rat Phospho-PTK2B / PYK2 (Tyr881) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1097 from LifeSpan Bioscience
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Mouse/Human/Rat Phospho-PTK2B / PYK2 (Tyr580) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1098 from LifeSpan Bioscience
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Mouse/Human/Rat Phospho-PTK2B / PYK2 (Tyr579) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1718 from LifeSpan Bioscience
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Mouse/Human/Rat PTK2B / PYK2 ELISA Kit (Cell-Based ELISA) - LS-F2276 from LifeSpan Bioscience
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Phosphotyrosine PTK2B / Protein-tyrosine Kinase 2-beta ELISA Kit - RAB0986 from Sigma-Aldrich
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Protein Kinase B, PKB, Human, ELISA Kit - E-EL-H1174 from ARP American Research Products
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Protein-tyrosine kinase 2-beta (PTK2B), Human, ELISA Kit - CSB-EL018994HU from ARP American Research Products
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Protein Tyrosine Kinase, PTK, Human, ELISA Kit - E-EL-H1192 from ARP American Research Products
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Protein Kinase B, PKB, Mouse, ELISA Kit - E-EL-M0972 from ARP American Research Products
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Protein Kinase B, PKB, Rat, ELISA Kit - E-EL-R0807 from ARP American Research Products
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Protein Kinase B, PKB, Rabbit, ELISA Kit - E-EL-RB1867 from ARP American Research Products
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PTK (Protein Tyrosine Kinase), Rabbit, ELISA Kit - E-EL-RB0440 from ARP American Research Products
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Protein Kinase B, PKB, Chicken, ELISA Kit - E-EL-Ch1464 from ARP American Research Products
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PTK (Protein Tyrosine Kinase), Chicken, ELISA Kit - E-EL-Ch1772 from ARP American Research Products
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Protein Kinase B, PKB, Porcine, ELISA Kit - E-EL-P2199 from ARP American Research Products
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PTK (Protein Tyrosine Kinase), Pig, ELISA Kit - E-EL-P0803 from ARP American Research Products
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Protein Kinase B, PKB, Guinea Pig, ELISA Kit - E-EL-GP1123 from ARP American Research Products
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PTK (Protein Tyrosine Kinase), Guinea Pig, ELISA Kit - E-EL-GP0441 from ARP American Research Products
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Protein Kinase B, PKB, Monkey, ELISA Kit - E-EL-MK0655 from ARP American Research Products
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PTK (Protein Tyrosine Kinase), Monkey, ELISA Kit - E-EL-MK2154 from ARP American Research Products
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PTK2B (Human) IP-WB Antibody Pair - H00002185-PW1 from Acris Antibodies
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PTK2B (Human) Matched Antibody Pair - H00002185-AP51 from Acris Antibodies
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Human Phospho-PYK2 (Y402) ELISA - PEL-PYK2-Y402 from RayBiotech
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Human PTK ELISA Kit - HP0743 from NeoScientific
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Anserine 8isoPGF2a ELISA Kit - AP0214 from NeoScientific
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