PTK2B

Gene Symbol	PTK2B
Entrez Gene	2185
Alt Symbol	CADTK, CAKB, FADK2, FAK2, PKB, PTK, PYK2, RAFTK
Species	Human
Gene Type	protein-coding
Description	protein tyrosine kinase 2 beta
Other Description	CAK-beta|FADK 2|PTK2B protein tyrosine kinase 2 beta|calcium-dependent tyrosine kinase|calcium-regulated non-receptor proline-rich tyrosine kinase|cell adhesion kinase beta|focal adhesion kinase 2|proline-rich tyrosine kinase 2|protein kinase B|protein-tyrosine kinase 2-beta|related adhesion focal tyrosine kinase
Swissprots	Q6PID4 Q14290 Q13475 Q16709 D3DST0 Q14289
Accessions	EAW63553 EAW63554 EAW63555 EAW63556 Q14289 AB209085 BAD92322 AK128371 BAC87404 AL120380 AW130888 AY429564 BC036651 AAH36651 BC042599 AAH42599 BF796371 BM712234 BQ009032 D45853 BAA08289 DA773624 DQ590775 L49207 AAB47217 U33284 AAC50203 U43522 AAC05330 XM_005273447 XP_005273504 XM_005273448 XP_005273505 XM_011544441 XP_011542743 XM_011544442 XP_011542744 NM_004103 NP_004094 NM_173174 NP_775266 NM_173175 NP_775267 NM_173176 NP_775268
Function	Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T- cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activati
Subcellular Location	Cytoplasm. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, focal adhesion. Cell projection, lamellipodium. Cytoplasm, cell cortex. Nucleus. Note=Interaction with NPHP1 induces the membrane-association of the kinase. Colocalizes with integrins at the cell periphery.
Tissue Specificity	Most abundant in the brain, with highest levels in amygdala and hippocampus. Low levels in kidney (at protein level). Also expressed in spleen and lymphocytes. {ECO:0000269|PubMed:7544443, ECO:0000269|PubMed:9545257}.
Top Pathways	Natural killer cell mediated cytotoxicity, Leukocyte transendothelial migration, GnRH signaling pathway, Calcium signaling pathway, Chemokine signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PYK2 full length protein - ab42622 from Abcam Category Protein Prices $321.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human PYK2 protein fragment - ab60878 from Abcam Category Protein Prices $294.00, $1,845.00 Sizes 10 µg, 100 µg Source Baculovirus infected sf9 cells Species Human

Human PYK2 (phospho T579) peptide - ab135942 from Abcam Category Peptide Species Human

Human PYK2 full length protein - ab152379 from Abcam Category Protein Source Wheat germ Species Human

Human PYK2 protein fragment - ab152380 from Abcam Category Protein Source Wheat germ Species Human

PTK2B / PYK2 Antibody Blocking Peptide - LS-E3138 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PTK2B / PYK2 Antibody Blocking Peptide - LS-E11487 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PYK2/FAK2 Recombinant Protein - H00002185-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 2 µg Species Human

PYK2/FAK2 Partial Recombinant Protein - H00002185-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PYK2/FAK2 Recombinant Protein - P3909 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 5 µg Species Human

PYK2/FAK2 Recombinant Protein - P4767 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

PYK2/FAK2 Peptide - P2747 from Novus Biologicals Category Peptide Species Human

PYK2-FAK2-Antibody-N-term-Blocking-peptide - BP7703a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Active PYK2/FAK2, CF - 4589-KS-010 from R&D Systems Category Protein

PTK2B Blocking Peptide - 33R-7611 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PTK2B Blocking Peptide - 33R-4661 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

FAK2 / PTK2B - H00002185-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

FAK2 / PTK2B - H00002185-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

FAK2 / PTK2B - H00002185-P01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Species Human

FAK2 / PTK2B - H00002185-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

FAK2 / PTK2B - H00002185-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

FAK2 / PTK2B - P3909 from Acris Antibodies Category Protein Prices $1,230.00 Sizes 5 µg Species Human

FAK2 / PTK2B - P4767 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

FAK2 / PTK2B - P5800 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

PTK2B fusion protein - Ag11487 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

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