| Gene Symbol |
OSBPL1A
|
| Entrez Gene |
114876
|
| Alt Symbol |
ORP-1, ORP1, OSBPL1B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
oxysterol binding protein-like 1A
|
| Other Description |
OSBP-related protein 1|oxysterol binding protein-like 1B|oxysterol-binding protein-related protein 1|oxysterol-binding protein-related protein 1 variant 1|oxysterol-binding protein-related protein 1 variant 2
|
| Swissprots |
B7Z7D3 Q9NW87 Q9BZF5 Q9BXW6
|
| Accessions |
ACA06034 ACA06035 EAX01180 EAX01181 EAX01182 EAX01183 Q9BXW6 AF274714 AAK15154 AF323726 AAG53407 AF392449 AAL40662 AF392450 AAL40663 AK001079 AK021898 AK096358 BAG53273 AK292895 BAF85584 AK301862 BAH13569 AK314552 BAG37138 BC007004 AAH07004 BC022293 BC041563 AAH41563 BC063420 AAH63420 BC073854 AAH73854 BC098384 AAH98384 BC136452 AAI36453 BC144117 AAI44118 BX647893 XM_006722380 XP_006722443 XM_006722381 XP_006722444 XM_006722382 XP_006722445 XM_006722383 XP_006722446 XM_011525800 XP_011524102 XR_935193 NM_001242508 NP_001229437 NM_018030 NP_060500 NM_080597 NP_542164 NM_133268
|
| Function |
Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. {ECO:0000250, ECO:0000269|PubMed:16176980}.
|
| Subcellular Location |
Late endosome {ECO:0000269|PubMed:16176980}. Note=Colocalizes with RAB7A, RAB9A and LAMP1 in late endosomes.
|