ITCH

Gene Symbol	ITCH
Entrez Gene	83737
Alt Symbol	ADMFD, AIF4, AIP4, NAPP1, dJ468O1.1
Species	Human
Gene Type	protein-coding
Description	itchy E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase Itchy homolog|NFE2-associated polypeptide 1|atrophin-1 interacting protein 4|dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4))|itchy E3 ubiquitin protein ligase homolog
Swissprots	Q9H4U5 E1P5P3 F5H217 Q9BY75 B4E234 Q9H451 Q96F66 Q5TEL0 Q5QP37 A6NEW4 Q96J02 O43584
Accessions	EAW76272 EAW76273 EAW76274 EAW76275 EAW76276 EAW76277 EAW76278 Q96J02 AA730741 AB056663 BAB39389 AB209747 BAD92984 AF038564 AAC04845 AF095745 AAK39399 AK297809 BAG60147 AK304090 BAG64996 AK315212 BAG37647 AL705688 BC006848 AAH06848 BC011571 AAH11571 DC307047 XM_005260570 XP_005260627 XM_011529077 XP_011527379 XM_011529078 XP_011527380 XM_011529079 XP_011527381 XR_244153 NM_001257137 NP_001244066 NM_001257138 NP_001244067 NM_031483 NP_113671
Function	Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation. It is involved in the control of inflammatory signaling pathways. Is an essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of the complex after TNF stimulation. Once the complex is formed, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1. Ubiquitinates RIPK2 by 'Lys-63'-linked conjugation and influences NOD2-dependent signal transduction pathways. Regulates the transcriptional ac
Subcellular Location	Cell membrane. Cytoplasm {ECO:0000250}. Nucleus. Note=Associates with endocytic vesicles. May be recruited to exosomes by NDFIP1.
Tissue Specificity	Widely expressed.
Top Pathways	Ubiquitin mediated proteolysis, Endocytosis, TNF signaling pathway, Non-alcoholic fatty liver disease (NAFLD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ITCH (D8Q6D) Rabbit mAb - 12117 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D8Q6D

AIP4 (D-20) - sc-11890 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

AIP4 (H-110) - sc-25625 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

AIP4 (C-15) - sc-11891 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

AIP4 (W-18) - sc-11887 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

AIP4 (G-11) - sc-28367 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Anti-ITCH/AIP4 (phospho Y420) antibody - ab111488 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ITCH/AIP4 antibody - ab31097 from Abcam Prices $390.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ITCH/AIP4 antibody - ab63940 from Abcam Prices $359.00 Sizes 100 µl Host Goat Clonality Polyclonal

Anti-ITCH/AIP4 antibody - ab79303 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ITCH/AIP4 antibody - ab169189 from Abcam Prices $376.00 Sizes 50 µl Host Mouse Clonality Polyclonal

Anti-ITCH/AIP4 antibody - ab99087 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ITCH/AIP4 antibody [EPR4936] - ab108515 from Abcam Prices $379.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR4936

Anti-ITCH/AIP4 antibody [EPR4937] - ab109018 from Abcam Prices $381.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR4937

Anti-ITCH/AIP4 antibody - Carboxyterminal end - ab70967 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ITCH/AIP4 antibody - N-terminal - ab181003 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ITCH / AIP4 Antibody (aa509-536, AP) - LS-C260449 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ITCH / AIP4 Antibody (aa509-536, Biotin) - LS-C260450 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ITCH / AIP4 Antibody (aa509-536, FITC) - LS-C260451 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ITCH / AIP4 Antibody (aa509-536, APC) - LS-C260452 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ITCH / AIP4 Antibody (phospho-Tyr420) - LS-C199148 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ITCH / AIP4 Antibody (aa509-536, PE) - LS-C260454 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ITCH / AIP4 Antibody (aa509-536, Azide-free, HRP) - LS-C260453 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ITCH / AIP4 Antibody (aa714-726) - LS-C55014 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-ITCH / AIP4 Antibody (aa508-536) - LS-C322289 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

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