ITCH

Gene Symbol	ITCH
Entrez Gene	83737
Alt Symbol	ADMFD, AIF4, AIP4, NAPP1, dJ468O1.1
Species	Human
Gene Type	protein-coding
Description	itchy E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase Itchy homolog|NFE2-associated polypeptide 1|atrophin-1 interacting protein 4|dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4))|itchy E3 ubiquitin protein ligase homolog
Swissprots	Q9H4U5 E1P5P3 F5H217 Q9BY75 B4E234 Q9H451 Q96F66 Q5TEL0 Q5QP37 A6NEW4 Q96J02 O43584
Accessions	EAW76272 EAW76273 EAW76274 EAW76275 EAW76276 EAW76277 EAW76278 Q96J02 AA730741 AB056663 BAB39389 AB209747 BAD92984 AF038564 AAC04845 AF095745 AAK39399 AK297809 BAG60147 AK304090 BAG64996 AK315212 BAG37647 AL705688 BC006848 AAH06848 BC011571 AAH11571 DC307047 XM_005260570 XP_005260627 XM_011529077 XP_011527379 XM_011529078 XP_011527380 XM_011529079 XP_011527381 XR_244153 NM_001257137 NP_001244066 NM_001257138 NP_001244067 NM_031483 NP_113671
Function	Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation. It is involved in the control of inflammatory signaling pathways. Is an essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of the complex after TNF stimulation. Once the complex is formed, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1. Ubiquitinates RIPK2 by 'Lys-63'-linked conjugation and influences NOD2-dependent signal transduction pathways. Regulates the transcriptional ac
Subcellular Location	Cell membrane. Cytoplasm {ECO:0000250}. Nucleus. Note=Associates with endocytic vesicles. May be recruited to exosomes by NDFIP1.
Tissue Specificity	Widely expressed.
Top Pathways	Ubiquitin mediated proteolysis, Endocytosis, TNF signaling pathway, Non-alcoholic fatty liver disease (NAFLD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human ITCH/AIP4 full length protein - ab190328 from Abcam Category Protein Prices $572.00 Sizes 100 µg Source E. coli Species Human

Human ITCH/AIP4 peptide - ab32426 from Abcam Category Peptide

Human ITCH/AIP4 protein fragment - ab153543 from Abcam Category Protein Source Wheat germ Species Human

ITCH / AIP4 Antibody Blocking Peptide - LS-E2575 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ITCH / AIP4 Antibody Blocking Peptide - LS-E15947 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ITCH / AIP4 Antibody Blocking Peptide - LS-E26276 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ITCH/AIP4 Partial Recombinant Protein - H00083737-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

ITCH/AIP4 Peptide - P0989 from Novus Biologicals Category Peptide Species Human

ITCH/AIP4 Peptide - P0988 from Novus Biologicals Category Peptide Species Human

ITCH-Antibody-Center-Blocking-peptide - BP13626c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ITCHAIP4-Antibody-C-Term-Blocking-peptide - BP2171b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ITCHAIP4-Antibody-N-Term-Blocking-peptide - BP2171a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ITCH blocking peptide - GTX88991-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

Recombinant Human ITCH/AIP4 Isoform 2, CF - E3-260-100 from R&D Systems Category Protein Source E. coli-derived,

ITCH Blocking Peptide - 33R-7623 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ITCH/AIP4 Peptide - AC21-1108-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

ITCH / AIF4 - H00083737-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ITCH / AIF4 - H00083737-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

AIF4 Peptide - 45-222P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

ITCH Peptide - 7645P from ProSci Category Peptide Species Human

ITCH fusion protein - Ag15120 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

ITCH fusion protein - Ag14688 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human ITCH, None tagged - ITCH-3094H from Creative Biomart Category Protein Source E. coli Species Human

ITCH - PN201740 from Elabscience Category Protein Prices $225.00, $475.00 Sizes 10 μg, 50 μg Source E. coli Species Human

Human ITCH / AIP4 Protein (aa 526-903) - 11131-HNCE-20 from Sino Biological Category Protein Prices $138.00, $348.00 Sizes 20 µg, 100 µg Source E. coli Species Human

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