| Gene Symbol |
Dmp1
|
| Entrez Gene |
25312
|
| Alt Symbol |
DENTMAT
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
dentin matrix acidic phosphoprotein 1
|
| Other Description |
AG1|DMP-1|dentin matrix protein 1
|
| Swissprots |
P98193
|
| Accessions |
EDL99499 P98193 BC129082 AAI29083 L11354 AAS55638 XM_006250622 XP_006250684 XM_008769994 XP_008768216 XM_008769995 XP_008768217 NM_203493 NP_987089
|
| Function |
May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed in tooth particularly in odontoblast and ameloblast.
|