Gene Symbol |
SH3BP1
|
Entrez Gene |
23616
|
Alt Symbol |
ARHGAP43
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
SH3-domain binding protein 1
|
Other Description |
3BP-1|SH3 domain binding protein 1|SH3 domain-binding protein 1
|
Swissprots |
Q9NSQ9 Q6ZVL9 Q5R3N0 Q96HQ5 Q6IBZ2 Q9Y3L3
|
Accessions |
EAW60171 EAW60172 EAW60173 EAW60174 Q9Y3L3 AK124370 BAC85842 AK126556 BAC86592 AK301163 BAH13419 AL157480 CAB75671 AW452539 AY364241 AAQ76800 BC008282 AAH08282 CR456576 CAG30462 CU013175 CAK54606 CU013463 CAK54905 DQ892658 ABM83584 DQ895898 ABM86824 NM_018957 NP_061830
|
Function |
Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac (By similarity). {ECO:0000250}.
|