| Gene Symbol |
PLSCR1
|
| Entrez Gene |
5359
|
| Alt Symbol |
MMTRA1B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phospholipid scramblase 1
|
| Other Description |
PL scramblase 1|ca(2+)-dependent phospholipid scramblase 1|erythrocyte phospholipid scramblase
|
| Swissprots |
O15162 B4DTE8 B2R8H8
|
| Accessions |
AAF80593 CCF77041 EAW78923 EAW78924 EAW78925 EAW78926 EAW78927 EAW78928 EAW78929 EAW78930 O15162 AB006746 BAA32568 AF098642 AAC99413 AK300181 BAG61960 AK313377 BAG36175 BC017901 AAH17901 BC021100 AAH21100 BC032718 AAH32718 BC070251 AAH70251 DQ890879 ABM81805 DQ894033 ABM84959 DR005513 XM_005247538 XP_005247595 XM_011512904 XP_011511206 XM_011512905 XP_011511207 XM_011512906 XP_011511208 XM_011512907 XP_011511209 NM_021105 NP_066928
|
| Function |
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
|
| Subcellular Location |
Cell membrane; Single-pass type II membrane protein. Membrane; Lipid-anchor; Cytoplasmic side. Nucleus.
|
| Tissue Specificity |
Expressed in platelets, erythrocyte membranes, lymphocytes, spleen, thymus, prostate, testis, uterus, intestine, colon, heart, placenta, lung, liver, kidney and pancreas. Not detected in brain and skeletal muscle.
|