Gene Symbol | PLSCR1 |
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Entrez Gene | 5359 |
Alt Symbol | MMTRA1B |
Species | Human |
Gene Type | protein-coding |
Description | phospholipid scramblase 1 |
Other Description | PL scramblase 1|ca(2+)-dependent phospholipid scramblase 1|erythrocyte phospholipid scramblase |
Swissprots | O15162 B4DTE8 B2R8H8 |
Accessions | AAF80593 CCF77041 EAW78923 EAW78924 EAW78925 EAW78926 EAW78927 EAW78928 EAW78929 EAW78930 O15162 AB006746 BAA32568 AF098642 AAC99413 AK300181 BAG61960 AK313377 BAG36175 BC017901 AAH17901 BC021100 AAH21100 BC032718 AAH32718 BC070251 AAH70251 DQ890879 ABM81805 DQ894033 ABM84959 DR005513 XM_005247538 XP_005247595 XM_011512904 XP_011511206 XM_011512905 XP_011511207 XM_011512906 XP_011511208 XM_011512907 XP_011511209 NM_021105 NP_066928 |
Function | May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. |
Subcellular Location | Cell membrane; Single-pass type II membrane protein. Membrane; Lipid-anchor; Cytoplasmic side. Nucleus. |
Tissue Specificity | Expressed in platelets, erythrocyte membranes, lymphocytes, spleen, thymus, prostate, testis, uterus, intestine, colon, heart, placenta, lung, liver, kidney and pancreas. Not detected in brain and skeletal muscle. |
PLSCR1 CRISPR/Cas9 KO Plasmid (h) - sc-402203 from Santa Cruz Biotechnology
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PLSCR1 HDR Plasmid (h) - sc-402203-HDR from Santa Cruz Biotechnology
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PLSCR1 Double Nickase Plasmid (h) - sc-402203-NIC from Santa Cruz Biotechnology
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PLSCR1 Double Nickase Plasmid (h2) - sc-402203-NIC-2 from Santa Cruz Biotechnology
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PLSCR1 CRISPR Activation Plasmid (h) - sc-402203-ACT from Santa Cruz Biotechnology
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PLSCR1 CRISPR Activation Plasmid (h2) - sc-402203-ACT-2 from Santa Cruz Biotechnology
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PLSCR1 Lentiviral Activation Particles (h) - sc-402203-LAC from Santa Cruz Biotechnology
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PLSCR1 Lentiviral Activation Particles (h2) - sc-402203-LAC-2 from Santa Cruz Biotechnology
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PLSCR1 siRNA (h) - sc-44028 from Santa Cruz Biotechnology
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PLSCR1 shRNA Plasmid (h) - sc-44028-SH from Santa Cruz Biotechnology
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PLSCR1 shRNA (h) Lentiviral Particles - sc-44028-V from Santa Cruz Biotechnology
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Phospholipid Scramblase 1/PLSCR1 RNAi - H00005359-R01 from Novus Biologicals
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MISSION® esiRNA - EHU023051 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17001 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17001 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07069 from Sigma-Aldrich
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PLSCR1 siRNA (Human) - CRH3597 from Cohesion Biosciences
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shRNA set against Human PLSCR1 (NM_021105.2) - SHH378072 from Creative biogene
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Human PLSCR1 siRNA - orb264099 from Biorbyt
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PLSCR1 shRNA Plasmid (Human) - CHH3597 from Cohesion Biosciences
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PLSCR1 miRNA 3'UTR clone - MiUTR3H-06611 from Creative biogene
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