| Gene Symbol |
TRPM3
|
| Entrez Gene |
80036
|
| Alt Symbol |
GON-2, LTRPC3, MLSN2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transient receptor potential cation channel, subfamily M, member 3
|
| Other Description |
LTrpC-3|long transient receptor potential channel 3|melastatin 2|melastatin-2|transient receptor potential cation channel subfamily M member 3
|
| Swissprots |
A2A3F6 Q86Z00 Q86UL0 Q9H0X2 Q86WK3 Q86YZ9 Q86WK2 Q86Z01 Q9HCF6 Q86WK4 A9Z1Y7 Q86SH0 Q86SH6 Q5W5T7 Q86WK1 Q5VW03 Q5VW04 Q5VW02
|
| Accessions |
EAW62505 EAW62506 EAW62507 EAW62508 EAW62509 EAW62510 EAW62511 Q9HCF6 AB046836 BAB13442 AB099661 BAC55102 AB099662 BAC55103 AB099663 BAC55104 AB099664 BAC55105 AB099665 BAC55106 AF325212 AAG42856 AF536748 AAO49153 AF536749 AAO49154 AF536750 AAO49155 AF536751 AAO49156 AF536752 AAO49157 AF536753 AAO49158 AJ505025 CAD43604 AJ505026 CAD43605 AK021788 BAB13895 AK225732 AK308682 AL136545 CAB66480 BC022454 AAH22454 BC067733 AAH67733 BC094699 AAH94699 BC121821 AAI21822 BC134414 AAI34415 BC142972 AAI42973 BC172350 AAI72350 BM668925 CD104154 CD673832 KF987075 AHI18585 XM_011519035 XP_011517337 XM_011519036 XP_011517338 XM_011519037 XP_011517339 XM_011519038 XP_011517340 XM_011519039 XP_011517341 XM_011519040 XP_011517342 XM_011519041 XP_011517343 XM_011519042 XP_011517344 XM_011519043 XP_011517345 XM_011519044 XP_011517346 XM_011519045 XP_011517347 XM_011519046 XP_011517348 XM_011519047 XP_011517349 NM_001007470 NP_001007471 NM_001007471 NP_001007472 NM_020952 NP_066003 NM_024971 NP_079247 NM_206944 NP_996827 NM_206945 NP_996828 NM_206946 NP_996829 NM_206947 NP_996830 NM_206948 NP_996831
|
| Function |
Calcium channel mediating constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation. {ECO:0000269|PubMed:12672799, ECO:0000269|PubMed:12672827}.
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:12672827}; Multi-pass membrane protein {ECO:0000269|PubMed:12672827}.
|
| Tissue Specificity |
Expressed primarily in the kidney and, at lower levels, in brain, testis, ovary, pancreas and spinal cord. Expression in the brain and kidney was determined at protein level. In the kidney, expressed predominantly in the collecting tubular epithelium in the medulla, medullary rays, and periglomerular regions; in the brain, highest levels are found in the cerebellum, choroid plexus, the locus coeruleus, the posterior thalamus and the substantia nigra. Down-regulated in renal tumors compared to normal kidney. {ECO:0000269|PubMed:12672799, ECO:0000269|PubMed:12672827}.
|