| Gene Symbol |
Chst7
|
| Entrez Gene |
302302
|
| Alt Symbol |
Gn6st-4
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
|
| Other Description |
C6ST-2|GST-5|N-acetylglucosamine 6-O-sulfotransferase 1|N-acetylglucosamine 6-O-sulfotransferase 4|carbohydrate sulfotransferase 7|chondroitin 6-sulfotransferase 2|chondroitin 6-sulfotransferase 7|galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 5|glcNAc6ST-4
|
| Swissprots |
Q2TA65 Q6XQG8
|
| Accessions |
EDL97689 Q6XQG8 AY216524 AAP51034 BC111079 AAI11080 NM_207600 NP_997483
|
| Function |
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N- acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Top Pathways |
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
|