Gene Symbol | Chst7 |
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Entrez Gene | 302302 |
Alt Symbol | Gn6st-4 |
Species | Rat |
Gene Type | protein-coding |
Description | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 |
Other Description | C6ST-2|GST-5|N-acetylglucosamine 6-O-sulfotransferase 1|N-acetylglucosamine 6-O-sulfotransferase 4|carbohydrate sulfotransferase 7|chondroitin 6-sulfotransferase 2|chondroitin 6-sulfotransferase 7|galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 5|glcNAc6ST-4 |
Swissprots | Q2TA65 Q6XQG8 |
Accessions | EDL97689 Q6XQG8 AY216524 AAP51034 BC111079 AAI11080 NM_207600 NP_997483 |
Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N- acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc (By similarity). {ECO:0000250}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Top Pathways | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate |
CompoZr® Knockout ZFN Kit - CKOZFN52053 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND52053 from Sigma-Aldrich
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CHST7 siRNA (Rat) - CRR4798 from Cohesion Biosciences
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CHST7 - MBS8211076 from MyBioSource
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shRNA set against Rat CHST7 (NM_207600.2) - SHH263849 from Creative biogene
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shRNA set against Rat Chst7(NM_207600.2) - SHG178054 from Creative biogene
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Rat CHST7 siRNA - orb299647 from Biorbyt
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CHST7 shRNA Plasmid (Rat) - CHR4798 from Cohesion Biosciences
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CHST7 miRNA 3'UTR clone - MiUTR1R-00998 from Creative biogene
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