| Gene Symbol |
SLC26A5
|
| Entrez Gene |
375611
|
| Alt Symbol |
DFNB61, PRES
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 26 (anion exchanger), member 5
|
| Other Description |
prestin|prestin (motor protein)
|
| Swissprots |
Q7Z7F3 Q86UG0 Q86UF9 P58743 Q496J2 Q86UF8
|
| Accessions |
EAW83334 EAW83335 P58743 AF523354 AAP31417 AK126898 AY256823 AAP31532 AY256824 AAP31533 AY256825 AAP31534 AY289133 AAP43685 AY289134 AAP43686 BC100832 AAI00833 BC100833 AAI00834 BC100834 AAI00835 BC100835 AAI00836 DA197655 XM_011516170 XP_011514472 NM_001167962 NP_001161434 NM_198999 NP_945350 NM_206883 NP_996766 NM_206884 NP_996767 NM_206885 NP_996768 NR_120441 NR_120442 NR_120443
|
| Function |
Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage- to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transpo
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Lateral wall of outer hair cells. {ECO:0000250}.
|