| Gene Symbol |
SH3GL1
|
| Entrez Gene |
6455
|
| Alt Symbol |
CNSA1, EEN, SH3D2B, SH3P8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SH3-domain GRB2-like 1
|
| Other Description |
EEN fusion partner of MLL|SH3 domain protein 2B|SH3 domain-containing GRB2-like protein 1|SH3-containing Grb-2-like 1 protein|endophilin-2|endophilin-A2|extra 11-19 leukemia fusion|extra eleven-nineteen leukemia fusion gene protein
|
| Swissprots |
E7EVZ4 B4DRA1 Q99961 Q99668 M0QZV5
|
| Accessions |
AAD24591 AAF04290 EAW69227 EAW69228 EAW69229 Q99961 AK097616 AK299166 BAG61213 AK315450 BAG37838 AY364240 AAQ76799 BC000089 AAH00089 BC001094 AAH01094 BC001270 AAH01270 BC014387 AAH14387 BC073825 BC098565 AAH98565 BU838380 CK820395 CR542087 CAG46884 DQ891258 ABM82184 DQ894444 ABM85370 U65999 AAB86800 X99656 CAA67970 XM_011528183 XP_011526485 NM_001199943 NP_001186872 NM_001199944 NP_001186873 NM_003025 NP_003016
|
| Function |
Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Early endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, podosome {ECO:0000269|PubMed:23285027}. Note=Associated with postsynaptic endosomes in hippocampal neurons. {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitous. Higher expression in pancreas, placenta, prostate, testis and uterus.
|
| Top Pathways |
Endocytosis
|
![Western Blot: EEN Overexpression Lysate (Adult Normal) [NBL1-15932] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for EEN.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1144_EEN%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15932-img0002.jpg)