TCF3

Gene Symbol TCF3
Entrez Gene 6929
Alt Symbol E2A, E47, ITF1, TCF-3, VDIR, bHLHb21
Species Human
Gene Type protein-coding
Description transcription factor 3
Other Description VDR interacting repressor|class B basic helix-loop-helix protein 21|helix-loop-helix protein HE47|immunoglobulin transcription factor 1|kappa-E2-binding factor|negative vitamin D response element-binding protein|transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)|transcription factor 3 variant 3|transcription factor E2-alpha|transcription factor ITF-1|vitamin D receptor-interacting repressor
Swissprots Q2TB40 Q2TB39 Q14636 Q9UPI9 Q14635 P15923 P15883 Q14208
Accessions AAC27373 AAC99797 CBX53848 EAW69467 EAW69468 EAW69469 EAW69470 EAW69471 EAW69472 P15923 AK024806 AK310998 AW028755 BC005166 BC011665 AAH11665 BC014680 BC110580 AAI10581 BG284440 BU528547 CD516687 CD674814 EU155120 KF303591 AGX32161 M24404 AAA56829 M24405 AAA56830 M31222 AAA52331 M31523 AAA61146 M65214 AAC41693 X52078 CAA36297 XM_006722852 XP_006722915 XM_006722853 XP_006722916 XM_006722855 XP_006722918 XM_006722856 XP_006722919 XM_006722857 XP_006722920 XM_006722858 XP_006722921 XM_011528215 XP_011526517 XM_011528216 XP_011526518 XM_011528217 XP_011526519 XM_011528218 XP_011526520 XM_011528219 XP_011526521 XM_011528220 XP_011526522 XM_011528221 XP_011526523 XM_011528222 XP_011526524 XM_011528223 XP_011526525 XM_011528224 XP_011526526 XM_011528225 XP_011526527 XM_011528226 XP_011526528 XM_011528227 XP_011526529 XR_430150 XR_430151 XR_430152 XR_430153 NM_001136139 NP_001129611 NM_003200 NP_003191
Function Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue- specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E- box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region.
Subcellular Location Nucleus.
Top Pathways HTLV-I infection, Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer

E2A Antibody - 4865 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using E2A Antibody.

E2A (D2B1) Rabbit mAb - 12258 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D2B1
Western blot analysis of extracts from various cell lines using E2A (D2B1) Rabbit mAb.

E2A (G-9) - sc-365261 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
E2A (G-9): sc-365261. Western blot analysis of E2A expression in K-562 whole cell lysate.

E2A (G-2) - sc-133075 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
E2A (G-2): sc-133075. Western blot analysis of E2A expression in Jurkat (A), K-562 (B) and SJRH30 (C) whole cell lysates.

E2A (H-208) - sc-762 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
E2A (H-208): sc-762. Western blot analysis of E2A expression in non-transfected 293T: sc-117752 (A), mouse E2A transfected 293T: sc-119880 (B) and Daudi (C) whole cell lysates.

E2A (N-649) - sc-763 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
E2A (N-649): sc-763. Western blot analysis of E2A expression in Jurkat (A) and K-562 (B) whole cell lysates.

E2A (P-18) - sc-385093 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

E2A (V-18) - sc-349 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
E2A (V-18): sc-349. Western blot analysis of E2A expression in Jurkat (A) and K-562 (B) whole cell lysates.

E2A (D-7) - sc-133074 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
E2A (D-7): sc-133074. Western blot analysis of E2A expression in Jurkat (A), K-562 (B) and SJRH30 (C) whole cell lysates.

E2A (Yae) - sc-416 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
E2A (Yae): sc-416. Western blot analysis of E47 expression in Jurkat (A) and K-562 (B) whole cell lysates.

Anti-TCF3 / E2A (phospho T355) antibody - ab85772 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TCF3 / E2A (phospho T355) antibody (ab85772) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate Lane 3 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate with Human TCF3 / E2A peptide (ab118180) at 1 µg/mlLane 4 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate with Human TCF3 / E2A peptide (ab118180) at 1 µg/mlLane 5 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate with Human TCF3 / E2A (phospho T355) peptide (ab103576) at 1 µg/mlLane 6 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate with Human TCF3 / E2A (phospho T355) peptide (ab103576) at 1 µg/mlLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-TCF3 / E2A (phospho T355) antibody - ab111839 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111839 at 1/50 dilution staining TCF3 / E2A in paraffin-embedded Human Brain tissue by Immunohistochemistry. The image on the right is treated with the synthesized phosphopeptide.

Anti-TCF3 / E2A (phospho T355) antibody - ChIP Grade - ab11176 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
IHC image of ab11176 staining in human kidney formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab11176, 1µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-TCF3 / E2A antibody - ab69999 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TCF3 / E2A antibody (ab69999) at 1/500 dilutionLane 1 : Extracts from 293 cells, minus immunising peptideLane 2 : Extracts from 293 cells, plus immunising peptide 5µgLysates/proteins at 5 µg per lane.

Anti-TCF3 / E2A antibody - ab59117 from Abcam

Prices $378.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-TCF3 / E2A antibody (ab59117) at 0.01 µg/ml + Daudi cell lysate in RIPA buffer at 35 µgdeveloped using the ECL technique

Anti-TCF3 / E2A antibody - ab82847 from Abcam

Prices $376.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
Anti-TCF3 / E2A antibody (ab82847) at 1/200 dilution + Primary Human keratinocyte cell lysate at 30 µgSecondaryanti-Rabbit IgG HRP at 1000

Anti-TCF3 / E2A antibody - ab58270 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-TCF3 / E2A antibody [6B8] - ab93921 from Abcam

Host Mouse
Clonality Monoclonal
Clone 6B8
All lanes : Anti-TCF3 / E2A antibody [6B8] (ab93921) at 1/500 dilutionLane 1 : A549 cell lysateLane 2 : A431 cell lysate Lane 3 : Hela cell lysate Lane 4 : PANC-1 cell lysateLane 5 : PC-3 cell lysate

Anti-TCF3 / E2A Antibody (aa522-535) IHC-plus™ - LS-B3248 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-TCF3 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3248 concentration 75 ug/ml.

Anti-TCF3 / E2A Antibody (C-Terminus) - LS-C14957 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-TCF3 / E2A Antibody (phospho-Thr355) - LS-C65114 from LifeSpan Bioscience

Prices $680.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TCF3 / E2A Antibody (aa505-554) - LS-C31812 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Jurkat Cell Lysate

Anti-TCF3 / E2A Antibody (aa100-500) - LS-C124640 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rat
Clonality Monoclonal

Anti-TCF3 / E2A Antibody (N-Terminus) - LS-C31363 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
A: Marker, B: HepG2 Cell Lysate

Anti-TCF3 / E2A Antibody - LS-C146850 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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