| Gene Symbol |
TCF3
|
| Entrez Gene |
6929
|
| Alt Symbol |
E2A, E47, ITF1, TCF-3, VDIR, bHLHb21
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transcription factor 3
|
| Other Description |
VDR interacting repressor|class B basic helix-loop-helix protein 21|helix-loop-helix protein HE47|immunoglobulin transcription factor 1|kappa-E2-binding factor|negative vitamin D response element-binding protein|transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)|transcription factor 3 variant 3|transcription factor E2-alpha|transcription factor ITF-1|vitamin D receptor-interacting repressor
|
| Swissprots |
Q2TB40 Q2TB39 Q14636 Q9UPI9 Q14635 P15923 P15883 Q14208
|
| Accessions |
AAC27373 AAC99797 CBX53848 EAW69467 EAW69468 EAW69469 EAW69470 EAW69471 EAW69472 P15923 AK024806 AK310998 AW028755 BC005166 BC011665 AAH11665 BC014680 BC110580 AAI10581 BG284440 BU528547 CD516687 CD674814 EU155120 KF303591 AGX32161 M24404 AAA56829 M24405 AAA56830 M31222 AAA52331 M31523 AAA61146 M65214 AAC41693 X52078 CAA36297 XM_006722852 XP_006722915 XM_006722853 XP_006722916 XM_006722855 XP_006722918 XM_006722856 XP_006722919 XM_006722857 XP_006722920 XM_006722858 XP_006722921 XM_011528215 XP_011526517 XM_011528216 XP_011526518 XM_011528217 XP_011526519 XM_011528218 XP_011526520 XM_011528219 XP_011526521 XM_011528220 XP_011526522 XM_011528221 XP_011526523 XM_011528222 XP_011526524 XM_011528223 XP_011526525 XM_011528224 XP_011526526 XM_011528225 XP_011526527 XM_011528226 XP_011526528 XM_011528227 XP_011526529 XR_430150 XR_430151 XR_430152 XR_430153 NM_001136139 NP_001129611 NM_003200 NP_003191
|
| Function |
Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue- specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E- box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region.
|
| Subcellular Location |
Nucleus.
|
| Top Pathways |
HTLV-I infection, Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer
|