Gene Symbol | NKX6-1 |
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Entrez Gene | 4825 |
Alt Symbol | NKX6.1, NKX6A |
Species | Human |
Gene Type | protein-coding |
Description | NK6 homeobox 1 |
Other Description | NK homeo box, family 6, member A|NK homeobox, family 6, A|NK6 transcription factor homolog A|NK6 transcription factor related, locus 1|homeobox protein NK-6 homolog A|homeobox protein Nkx-6.1 |
Swissprots | P78426 |
Accessions | AAD11962 EAX05949 P78426 BC160030 AAI60030 XM_006714230 XP_006714293 NM_006168 NP_006159 |
Function | Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is involved in regulation of the insulin gene. Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Tissue Specificity | Pancreatic beta cells. |
Top Pathways | Maturity onset diabetes of the young |
Nkx-6.1 (C-14) - sc-15030 from Santa Cruz Biotechnology
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Nkx-6.1 (N-15) - sc-15027 from Santa Cruz Biotechnology
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Nkx-6.1 (5B8) - sc-130385 from Santa Cruz Biotechnology
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Anti-nkx6.1 antibody - ab129659 from Abcam
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Anti-nkx6.1 antibody - ab90706 from Abcam
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Anti-nkx6.1 antibody - ab123412 from Abcam
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Anti-nkx6.1 antibody - C-terminal - ab199906 from Abcam
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Anti-NKX6-1 Antibody (aa1-120) - LS-C124275 from LifeSpan Bioscience
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Anti-NKX6-1 Antibody (aa50-200, DY650) - LS-C143536 from LifeSpan Bioscience
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Anti-NKX6-1 Antibody (aa50-200, Biotin) - LS-C143535 from LifeSpan Bioscience
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Anti-NKX6-1 Antibody (aa50-200, HRP) - LS-C143538 from LifeSpan Bioscience
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Anti-NKX6-1 Antibody (aa1-120) - LS-C144076 from LifeSpan Bioscience
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Anti-NKX6-1 Antibody (aa50-200, DY550) - LS-C143539 from LifeSpan Bioscience
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Anti-NKX6-1 Antibody (aa50-200, DY488) - LS-C143537 from LifeSpan Bioscience
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Anti-NKX6-1 Antibody (aa284-312, APC) - LS-C215994 from LifeSpan Bioscience
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Anti-NKX6-1 Antibody (aa284-312, AP) - LS-C215995 from LifeSpan Bioscience
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Anti-NKX6-1 Antibody (aa284-312, FITC) - LS-C215996 from LifeSpan Bioscience
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Anti-NKX6-1 Antibody (aa284-312, PE) - LS-C215997 from LifeSpan Bioscience
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Anti-NKX6-1 Antibody (aa285-314, AP) - LS-C215998 from LifeSpan Bioscience
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Anti-NKX6-1 Antibody (aa285-314, APC) - LS-C215999 from LifeSpan Bioscience
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Anti-NKX6-1 Antibody (aa50-200) - LS-C143534 from LifeSpan Bioscience
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Anti-NKX6-1 Antibody (N-Terminus) - LS-C109702 from LifeSpan Bioscience
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Anti-NKX6-1 Antibody (clone 1B7) - LS-C197787 from LifeSpan Bioscience
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Anti-NKX6-1 Antibody (aa285-314, FITC) - LS-C216000 from LifeSpan Bioscience
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Anti-NKX6-1 Antibody (aa285-314, PE) - LS-C216001 from LifeSpan Bioscience
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