Gene Symbol | NKX6-1 |
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Entrez Gene | 4825 |
Alt Symbol | NKX6.1, NKX6A |
Species | Human |
Gene Type | protein-coding |
Description | NK6 homeobox 1 |
Other Description | NK homeo box, family 6, member A|NK homeobox, family 6, A|NK6 transcription factor homolog A|NK6 transcription factor related, locus 1|homeobox protein NK-6 homolog A|homeobox protein Nkx-6.1 |
Swissprots | P78426 |
Accessions | AAD11962 EAX05949 P78426 BC160030 AAI60030 XM_006714230 XP_006714293 NM_006168 NP_006159 |
Function | Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is involved in regulation of the insulin gene. Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Tissue Specificity | Pancreatic beta cells. |
Top Pathways | Maturity onset diabetes of the young |
NKX6-1 Antibody Blocking Peptide - LS-E3279 from LifeSpan Bioscience
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NKX6-1 Antibody Blocking Peptide - LS-E4302 from LifeSpan Bioscience
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NKX6-1-Antibody-C-term-Blocking-Peptide - BP14437b from Abgent, a WuXi AppTec company
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NKX6-1-Antibody-C-term-Blocking-Peptide - BP16589b from Abgent, a WuXi AppTec company
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Recombinant Human NKX6-1 - NKX6-1-600H from Creative Biomart
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Recombinant NK6 Homeobox Protein 1 (NKX6-1) - RPG781Hu01 from Uscn Life Science Inc.
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Recombinant NK6 Homeobox Protein 1 (NKX6-1) - RPG781Hu01 from Cloud-clone
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Recombinant Human Homeobox protein Nkx-6.1(NKX6-1) - CSB-YP015850HU CSB-EP015850HU CSB-BP015850HU CSB-MP015850HU from Cusabio
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NKX6-1 Peptide, Human - M34GP10418H from Creative Peptides
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NKX6.1 Recombinant Protein Antigen - NBP1-82553PEP from Novus Biologicals
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NKX6-1 peptide - orb13059 from Biorbyt
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NKX6-1 Recombinant Protein (OPCD05679) - OPCD05679 from Aviva Systems Biology
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Homeobox protein Nkx-6.1 (NKX6-1), Recombinant Protein - MBS951083 from MyBioSource
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