Egln1

Gene Symbol	Egln1
Entrez Gene	112405
Alt Symbol	AI503754, C1orf12, HIF-PH2, HPH-2, Hif-p4h-2, ORF13, Phd2, SM-20
Species	Mouse
Gene Type	protein-coding
Description	egl-9 family hypoxia-inducible factor 1
Other Description	HIF-prolyl hydroxylase 2|egl nine homolog 1|hypoxia-inducible factor prolyl hydroxylase 2|prolyl hydroxylase domain-containing protein 2
Swissprots	Q91YE3 Q922P3 Q8VHJ2
Accessions	EDL11790 Q91YE3 AF453878 AAL65165 AJ310546 CAC42515 AK084519 BC006903 AAH06903 BC083146 AAH83146 CJ181087 XM_006530578 XP_006530641 NM_053207 NP_444437
Function	Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferencially recogniz
Subcellular Location	Cytoplasm {ECO:0000250|UniProtKB:Q9GZT9}. Nucleus {ECO:0000250|UniProtKB:Q9GZT9}. Note=Mainly cytoplasmic. Shuttles between the nucleus and cytoplasm. Nuclear export requires functional XPO1. {ECO:0000250|UniProtKB:Q9GZT9}.
Tissue Specificity	Expressed in heart, brain liver, skeletal muscle and kidney. Low levels were detected in the lung. Constitutively expressed during differentiation of C2C12 skeletal myocytes. {ECO:0000269|PubMed:12234095}.
Top Pathways	Renal cell carcinoma

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Egl Nine Homolog 1 (EGLN1), Mouse, ELISA Kit - SEL644Mu from ARP American Research Products Category ELISA Kit Prices $812.00 Sizes 96 t Sensitivity 0.108ng/mL Range 0.312-20ng/mL

Egl Nine Homolog 1, ELISA Kit - MBS091414 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 10 pg/ml. Range 62.5 pg/ml - 2000 pg/ml.

ELISA Kit for Egl Nine Homolog 1 (EGLN1) - SEL644Mu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.108ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Mouse Egl Nine Homolog 1 (EGLN1) ELISA Kit - EKU03837 from Biomatik Category ELISA Kit Prices $832.00, $3,659.00, $6,653.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.116 ng/mL Range 0.312-20 ng/mL

Mouse Egl Nine Homolog 1 ELISA Kit - abx153943 from Abbexa Category ELISA Kit Sensitivity 0.108 ng/ml Range 0.313 ng/ml - 20 ng/ml

Egl Nine Homolog 1 (EGLN1), Mouse, ELISA Kit - DL-EGLN1-Mu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Range 0.312-20 ng/mL

Mouse EGLN1 ELISA Kit - orb369918 from Biorbyt Category ELISA Kit Prices $604.00, $689.00 Sizes 48 test, 96 test Range Detection Range: 0.313-20ng/mL Detection low threshold: 0.108ng/mL

Mouse EGLN1 ELISA Kit - abx572849 from Abbexa Category ELISA Kit Sensitivity 0.108 ng/ml Range 0.313 ng/ml - 20 ng/ml

Mouse Egln1 ELISA Kit - E051612 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of EGLN1 is typically less than 0.116ng/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by adding tw

Egln1 ELISA Kit (Mouse) (OKCD02055) - OKCD02055 from Aviva Systems Biology Category ELISA Kit Prices $600.00 Sizes 96 wells Sensitivity < 0.116 ng/mL Range 0.312 - 20 ng/mL

Mouse Egl nine homolog 1 (EGLN1) ELISA Kit - AE46021MO from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 0.116 ng/mL Range 0.312-20 ng/mL

Egl Nine Homolog 1 (EGLN1), ELISA Kit - MBS451161 from MyBioSource Category ELISA Kit Prices $455.00, $605.00, $2,685.00, $5,220.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.108ng/mL Range 0.312-20ng/mL

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