Egln1

Gene Symbol Egln1
Entrez Gene 112405
Alt Symbol AI503754, C1orf12, HIF-PH2, HPH-2, Hif-p4h-2, ORF13, Phd2, SM-20
Species Mouse
Gene Type protein-coding
Description egl-9 family hypoxia-inducible factor 1
Other Description HIF-prolyl hydroxylase 2|egl nine homolog 1|hypoxia-inducible factor prolyl hydroxylase 2|prolyl hydroxylase domain-containing protein 2
Swissprots Q91YE3 Q922P3 Q8VHJ2
Accessions EDL11790 Q91YE3 AF453878 AAL65165 AJ310546 CAC42515 AK084519 BC006903 AAH06903 BC083146 AAH83146 CJ181087 XM_006530578 XP_006530641 NM_053207 NP_444437
Function Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferencially recogniz
Subcellular Location Cytoplasm {ECO:0000250|UniProtKB:Q9GZT9}. Nucleus {ECO:0000250|UniProtKB:Q9GZT9}. Note=Mainly cytoplasmic. Shuttles between the nucleus and cytoplasm. Nuclear export requires functional XPO1. {ECO:0000250|UniProtKB:Q9GZT9}.
Tissue Specificity Expressed in heart, brain liver, skeletal muscle and kidney. Low levels were detected in the lung. Constitutively expressed during differentiation of C2C12 skeletal myocytes. {ECO:0000269|PubMed:12234095}.
Top Pathways Renal cell carcinoma

Recombinant Egl Nine Homolog 1 (EGLN1) - RPL644Mu01 from Cloud-clone

Category Protein
Source E.coli
Species Mouse

Recombinant Egl Nine Homolog 1 (EGLN1) - RPL644Mu02 from Cloud-clone

Category Protein
Source E.coli
Species Mouse

Recombinant Mouse Egl nine homolog 1(Egln1) - CSB-YP821019MO CSB-EP821019MO CSB-BP821019MO CSB-MP821019MO from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Mouse

Recombinant Mouse EGLN1 Protein - EGLN1-5049M from Creative Biomart

Category Protein
Source Mammalian Cells
Species Mouse

Egl nine homolog 1 (Egln1), Recombinant Protein - MBS1314092 from MyBioSource

Category Protein
Prices $1,170.00, $1,170.00, $1,400.00, $1,400.00, $1,875.00, $1,875.00, $2,340.00, $2,340.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Mouse
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