| Gene Symbol | FOXN4 |
|---|---|
| Entrez Gene | 121643 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | forkhead box N4 |
| Other Description | forkhead box protein N4|forkhead/winged helix transcription factor FOXN4 |
| Swissprots | Q96NZ1 Q96NZ0 Q6ZMR4 |
| Accessions | EAW97856 EAW97857 Q96NZ1 AA421288 AF425596 AAL23949 AF425597 AAL23950 AK093286 AK131519 BAD18661 BC113073 AAI13074 BC146825 AAI46826 XM_011537919 XP_011536221 XM_011537920 XP_011536222 XM_011537921 XP_011536223 XM_011537922 XP_011536224 XM_011537923 XP_011536225 NM_213596 NP_998761 |
| Function | Transcription factor essential for neural and some non- neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4- NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal and is indirectly required for patterning the distal airway during lung development (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00089}. |
forkhead box N4, ELISA Kit - MBS9331579 from MyBioSource
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Human FOXN4 ELISA Kit - E015383 from Biobool
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