Gene Symbol | SPTSSA |
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Entrez Gene | 171546 |
Alt Symbol | C14orf147, SSSPTA |
Species | Human |
Gene Type | protein-coding |
Description | serine palmitoyltransferase, small subunit A |
Other Description | serine palmitoyltransferase small subunit A|small subunit of serine palmitoyltransferase A |
Swissprots | Q8WTZ7 B2RD54 Q969W0 D3DS93 |
Accessions | EAW65923 EAW65924 Q969W0 AI765163 AK001993 AK315409 BAG37801 AL080066 BC016805 AAH16805 BC016808 AAH16808 BC021701 AAH21701 BC068480 AAH68480 HQ447916 ADQ32400 NM_138288 NP_612145 |
Function | Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2- SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16- CoA as substrates, with a slight preference for C14-CoA. {ECO:0000269|PubMed:19416851}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
SPTSSA CRISPR/Cas9 KO Plasmid (h) - sc-410366 from Santa Cruz Biotechnology
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SPTSSA HDR Plasmid (h) - sc-410366-HDR from Santa Cruz Biotechnology
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SPTSSA Double Nickase Plasmid (h) - sc-410366-NIC from Santa Cruz Biotechnology
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SPTSSA Double Nickase Plasmid (h2) - sc-410366-NIC-2 from Santa Cruz Biotechnology
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SPTSSA CRISPR Activation Plasmid (h) - sc-410366-ACT from Santa Cruz Biotechnology
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SPTSSA CRISPR Activation Plasmid (h2) - sc-410366-ACT-2 from Santa Cruz Biotechnology
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SPTSSA Lentiviral Activation Particles (h) - sc-410366-LAC from Santa Cruz Biotechnology
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SPTSSA Lentiviral Activation Particles (h2) - sc-410366-LAC-2 from Santa Cruz Biotechnology
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SPTSSA siRNA (h) - sc-92363 from Santa Cruz Biotechnology
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SPTSSA shRNA Plasmid (h) - sc-92363-SH from Santa Cruz Biotechnology
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SPTSSA shRNA (h) Lentiviral Particles - sc-92363-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU004451 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4324 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4324 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11227 from Sigma-Aldrich
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SPTSSA siRNA (Human) - CRJ6147 from Cohesion Biosciences
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SPTSSA - MBS8212006 from MyBioSource
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shRNA set against Human C14orf147 (NM_138288.3) - SHH249370 from Creative biogene
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SPTSSA shRNA Plasmid (Human) - CHJ6147 from Cohesion Biosciences
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SPTSSA miRNA 3'UTR clone - MiUTR1H-01102 from Creative biogene
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