Gene Symbol | DVL1 |
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Entrez Gene | 1855 |
Alt Symbol | DVL, DVL1L1, DVL1P1 |
Species | Human |
Gene Type | protein-coding |
Description | dishevelled segment polarity protein 1 |
Other Description | DSH homolog 1|dishevelled 1 (homologous to Drosophila dsh)|dishevelled, dsh homolog 1|dishevelled-1|segment polarity protein dishevelled homolog DVL-1 |
Swissprots | O14640 Q5TA35 Q5TA33 |
Accessions | EAW56224 EAW56225 EAW56226 EAW56227 O14640 P54792 AB209210 BAD92447 AF006011 AAB65242 AK093189 BAC04089 AK095867 BAG53150 AK293286 BAH11484 AK300063 BAH13201 BC017225 AAH17225 BC025292 BC050454 AAH50454 BC111419 BP305846 U46461 AAC50682 XM_005244731 XP_005244788 XM_005244732 XP_005244789 XM_005244733 XP_005244790 NM_004421 NP_004412 NM_181870 NM_182779 |
Function | Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). |
Subcellular Location | Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Localizes at the cell membrane upon interaction with frizzled family members. {ECO:0000250}. |
Top Pathways | Wnt signaling pathway, Notch signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection |
dishevelled, dsh homolog 1 (Drosophila) , ELISA Kit - MBS9340777 from MyBioSource
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dishevelled, dsh homolog 1 (Drosophila) -like 1, ELISA Kit - MBS9323395 from MyBioSource
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Mouse DVL1 / DVL / Dishevelled ELISA Kit (Custom ELISA) - LS-F17856 from LifeSpan Bioscience
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Rat DVL1 / DVL / Dishevelled ELISA Kit (Custom ELISA) - LS-F17855 from LifeSpan Bioscience
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Human DVL1 / DVL / Dishevelled ELISA Kit (Custom ELISA) - LS-F17857 from LifeSpan Bioscience
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DVL1 ELISA Kit (Human) (OKEH02504) - OKEH02504 from Aviva Systems Biology
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Human Segment polarity protein dishevelled homolog DVL-1 ELISA Kit - EK3654 from Signalway Antibody
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Segment polarity protein dishevelled homolog DVL-1, ELISA Kit - MBS9427488 from MyBioSource
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Segment polarity protein dishevelled homolog DVL-1, ELISA Kit - MBS2881603 from MyBioSource
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Segment polarity protein dishevelled homolog DVL-1, ELISA Kit - MBS760715 from MyBioSource
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Human DVL1 / DVL / Dishevelled ELISA Kit (Sandwich ELISA) - LS-F33368 from LifeSpan Bioscience
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