| Gene Symbol |
DVL1
|
| Entrez Gene |
1855
|
| Alt Symbol |
DVL, DVL1L1, DVL1P1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dishevelled segment polarity protein 1
|
| Other Description |
DSH homolog 1|dishevelled 1 (homologous to Drosophila dsh)|dishevelled, dsh homolog 1|dishevelled-1|segment polarity protein dishevelled homolog DVL-1
|
| Swissprots |
O14640 Q5TA35 Q5TA33
|
| Accessions |
EAW56224 EAW56225 EAW56226 EAW56227 O14640 P54792 AB209210 BAD92447 AF006011 AAB65242 AK093189 BAC04089 AK095867 BAG53150 AK293286 BAH11484 AK300063 BAH13201 BC017225 AAH17225 BC025292 BC050454 AAH50454 BC111419 BP305846 U46461 AAC50682 XM_005244731 XP_005244788 XM_005244732 XP_005244789 XM_005244733 XP_005244790 NM_004421 NP_004412 NM_181870 NM_182779
|
| Function |
Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Localizes at the cell membrane upon interaction with frizzled family members. {ECO:0000250}.
|
| Top Pathways |
Wnt signaling pathway, Notch signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection
|
![Western Blot: Dishevelled/Dvl1 Overexpression Lysate (Adult Normal) [NBL1-10061] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Dishevelled/Dvl1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1264_Dishevelled-Dvl1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10061-img0002.jpg)
![Western Blot: Dishevelled/Dvl1 Overexpression Lysate (Adult Normal) [NBL1-10062] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Dishevelled/Dvl1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3278_Dishevelled-Dvl1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10062-img0002.jpg)