RASGRP2

Gene Symbol	RASGRP2
Entrez Gene	10235
Alt Symbol	CALDAG-GEFI, CDC25L
Species	Human
Gene Type	protein-coding
Description	RAS guanyl releasing protein 2 (calcium and DAG-regulated)
Other Description	F25B3.3 kinase-like protein|RAS guanyl nucleotide-releasing protein 2|RAS guanyl-releasing protein 2|calcium and DAG-regulated guanine nucleotide exchange factor I|calcium and diacylglycerol-regulated guanine nucleotide exchange factor I|cdc25-like protein|guanine exchange factor MCG7|hCDC25L
Swissprots	A6NDC7 Q9UL65 O00538 Q7LDG7
Accessions	CAI45372 EAW74281 EAW74282 EAW74283 Q7LDG7 AF043722 AAF07219 AF043723 AAF07220 AF081194 AAC79698 AK092852 AK092882 BAG52620 AK122694 BAG53672 AK124023 AK314637 BAG37199 BC110306 AAI10307 BC117151 AAI17152 DA286186 DB498812 HQ258466 ADR83220 U78170 AAD12741 Y12336 CAA73005 XM_005273707 XP_005273764 XM_011544718 XP_011543020 XM_011544719 XP_011543021 XM_011544720 XP_011543022 XM_011544721 XP_011543023 XM_011544722 XP_011543024 XM_011544723 XP_011543025 XM_011544724 XP_011543026 XM_011544725 XP_011543027 NM_001098670 NP_001092140 NM_001098671 NP_001092141 NM_153819 NP_722541 NM_005825
Function	Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. {ECO:0000269|PubMed:10918068, ECO:0000269|PubMed:14702343, ECO:0000269|PubMed:17576779, ECO:0000269|PubMed:17702895, ECO:0000269|PubMed:24958846}.
Subcellular Location	Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome {ECO:0000305}. Cell projection, ruffle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Found both in the cytosol and associated with membranes. Isoform 2 mainly localizes to the cell membrane. Enriched at juxtamembrane areas and membrane ruffles through association with F-actin. Localizes to the cell bodies and axons of striatal neurons (By similarity). {ECO:0000250}.
Tissue Specificity	Detected in platelets, neutrophils and T lymphocytes (at protein level). Expressed in brain where it is enriched in the striatum. Also expressed in the hematopoietic system. Detected in heart, brain, lung, placenta, liver, skeletal muscle and kidney. {ECO:0000269|PubMed:10918068, ECO:0000269|PubMed:17576779, ECO:0000269|PubMed:17702895, ECO:0000269|PubMed:9341881, ECO:0000269|PubMed:9789079}.
Top Pathways	MAPK signaling pathway, Chemokine signaling pathway, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RASGRP2 Antibody Blocking Peptide - LS-E1475 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RASGRP2 Protein - H00010235-P02 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human RASGRP2 Protein - H00010235-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human RASGRP2 Protein - H00010235-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RASGRP2-Antibody-N-term-Blocking-peptide - BP12183a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RASGRP2 Blocking Peptide - 33R-5537 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RASGRP2 - H00010235-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

RASGRP2 - H00010235-P02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

RASGRP2 - H00010235-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RASGRP2 - H00010235-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Human RASGRP2, His-tagged - RASGRP2-31042TH from Creative Biomart Category Protein Source E. coli

Recombinant Human RAS guanyl-releasing protein 2(RASGRP2) - CSB-YP752103HU CSB-EP752103HU CSB-BP752103HU CSB-MP752103HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RASGRP2 (transcript variant 3) - TP312672 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

RASGRP2 (transcript variant 4) - TP312719 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

RASGRP2 (transcript variant 2) - TP317525 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

RASGRP2 Recombinant Protein Antigen - NBP1-86661PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RASGRP2-Blocking-Peptide-N-term - BP21681a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RASGRP2 Peptide, Human - M34GP13000H from Creative Peptides Category Peptide Source Synthetic. Species Human

RAS guanyl-releasing protein 2 (RASGRP2), Recombinant Protein - MBS1477472 from MyBioSource Category Protein Prices $1,400.00, $1,400.00, $1,630.00, $1,630.00, $2,365.00, $2,365.00, $2,810.00, $2,810.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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