Gene Symbol | Atg9a |
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Entrez Gene | 245860 |
Alt Symbol | AU019532, Apg9l1, Atg9, Atg9l1 |
Species | Mouse |
Gene Type | protein-coding |
Description | autophagy related 9A |
Other Description | APG9 autophagy 9-like 1|APG9-like 1|autophagy protein 9|autophagy-related 9-like 1|autophagy-related 9A|autophagy-related protein 9A |
Swissprots | Q68FE2 |
Accessions | EDL00374 EDL00375 Q68FE2 AK043624 BAC31599 AK195501 AK203199 AK205404 AK210178 AM085510 CAJ30208 AU019532 BC034139 AAH34139 BC056488 BC079884 AAH79884 BC082307 BK004020 DAA05201 XM_011238687 XP_011236989 XM_011238688 XP_011236990 XM_011238689 XP_011236991 XM_011238690 XP_011236992 NM_001003917 NP_001003917 NM_001288612 NP_001275541 NM_001288613 NP_001275542 NR_109938 |
Function | Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H (By similarity). Required for carbonyl cyanide m-chlorophenylhydrazone (CCCP)-induced ATG8 family proteins lipidation, a key autophagy step. {ECO:0000250, ECO:0000269|PubMed:23402761}. |
Subcellular Location | Cytoplasmic vesicle, autophagosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Late endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
Atg9a CRISPR/Cas9 KO Plasmid (m) - sc-434176 from Santa Cruz Biotechnology
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Atg9a HDR Plasmid (m) - sc-434176-HDR from Santa Cruz Biotechnology
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Atg9a Double Nickase Plasmid (m) - sc-434176-NIC from Santa Cruz Biotechnology
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Atg9a Double Nickase Plasmid (m2) - sc-434176-NIC-2 from Santa Cruz Biotechnology
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Atg9a CRISPR Activation Plasmid (m) - sc-434176-ACT from Santa Cruz Biotechnology
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Atg9a CRISPR Activation Plasmid (m2) - sc-434176-ACT-2 from Santa Cruz Biotechnology
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Atg9a Lentiviral Activation Particles (m) - sc-434176-LAC from Santa Cruz Biotechnology
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Atg9a Lentiviral Activation Particles (m2) - sc-434176-LAC-2 from Santa Cruz Biotechnology
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Atg9a siRNA (m) - sc-72587 from Santa Cruz Biotechnology
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Atg9a shRNA Plasmid (m) - sc-72587-SH from Santa Cruz Biotechnology
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Atg9a shRNA (m) Lentiviral Particles - sc-72587-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU071471 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN27159 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND27159 from Sigma-Aldrich
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ATG9A siRNA (Mouse) - CRN3809 from Cohesion Biosciences
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ATG9A - MBS8210969 from MyBioSource
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shRNA set against Mouse ATG9 (NM_001003917.3) - SHH242190 from Creative biogene
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shRNA set against Mouse Atg9a(NM_001003917.3) - SHG080245 from Creative biogene
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ATG9A shRNA Plasmid (Mouse) - CHN3809 from Cohesion Biosciences
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ATG9A miRNA 3'UTR clone - MiUTR1M-01785 from Creative biogene
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