| Gene Symbol |
TIMM10
|
| Entrez Gene |
26519
|
| Alt Symbol |
TIM10, TIM10A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
translocase of inner mitochondrial membrane 10 homolog (yeast)
|
| Other Description |
mitochondrial import inner membrane translocase subunit Tim10
|
| Swissprots |
P62072 A8K136
|
| Accessions |
EAW73753 P62072 AF150089 AAD39995 AF152354 AAF15104 AI498204 AK289751 BAF82440 BC032133 AAH32133 CB106298 DQ579709 NM_012456 NP_036588
|
| Function |
Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. {ECO:0000269|PubMed:14726512}.
|
| Subcellular Location |
Mitochondrion inner membrane {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:14726512}; Peripheral membrane protein {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:14726512}; Intermembrane side {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:14726512}.
|
| Tissue Specificity |
Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle. {ECO:0000269|PubMed:10552927, ECO:0000269|PubMed:10611480}.
|