Gene Symbol | TIMM10 |
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Entrez Gene | 26519 |
Alt Symbol | TIM10, TIM10A |
Species | Human |
Gene Type | protein-coding |
Description | translocase of inner mitochondrial membrane 10 homolog (yeast) |
Other Description | mitochondrial import inner membrane translocase subunit Tim10 |
Swissprots | P62072 A8K136 |
Accessions | EAW73753 P62072 AF150089 AAD39995 AF152354 AAF15104 AI498204 AK289751 BAF82440 BC032133 AAH32133 CB106298 DQ579709 NM_012456 NP_036588 |
Function | Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. {ECO:0000269|PubMed:14726512}. |
Subcellular Location | Mitochondrion inner membrane {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:14726512}; Peripheral membrane protein {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:14726512}; Intermembrane side {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:14726512}. |
Tissue Specificity | Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle. {ECO:0000269|PubMed:10552927, ECO:0000269|PubMed:10611480}. |
Tim10 CRISPR/Cas9 KO Plasmid (h) - sc-406864 from Santa Cruz Biotechnology
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Tim10 HDR Plasmid (h) - sc-406864-HDR from Santa Cruz Biotechnology
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Tim10 Double Nickase Plasmid (h) - sc-406864-NIC from Santa Cruz Biotechnology
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Tim10 Double Nickase Plasmid (h2) - sc-406864-NIC-2 from Santa Cruz Biotechnology
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Tim10 CRISPR Activation Plasmid (h) - sc-406864-ACT from Santa Cruz Biotechnology
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Tim10 CRISPR Activation Plasmid (h2) - sc-406864-ACT-2 from Santa Cruz Biotechnology
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Tim10 Lentiviral Activation Particles (h) - sc-406864-LAC from Santa Cruz Biotechnology
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Tim10 Lentiviral Activation Particles (h2) - sc-406864-LAC-2 from Santa Cruz Biotechnology
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Tim10 siRNA (h) - sc-41255 from Santa Cruz Biotechnology
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Tim10 shRNA Plasmid (h) - sc-41255-SH from Santa Cruz Biotechnology
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Tim10 shRNA (h) Lentiviral Particles - sc-41255-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU054071 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21356 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21356 from Sigma-Aldrich
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TIMM10 siRNA (Human) - CRH8844 from Cohesion Biosciences
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TIMM10 - MBS8236635 from MyBioSource
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shRNA set against Human TIMM10 (NM_012456.2) - SHH427372 from Creative biogene
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shRNA set against Human TIMM10(NM_012456.2) - SHL071040 from Creative biogene
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Human TIMM10 siRNA - orb269346 from Biorbyt
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TIMM10 shRNA Plasmid (Human) - CHH8844 from Cohesion Biosciences
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TIMM10 miRNA 3'UTR clone - MiUTR1H-10411 from Creative biogene
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