Gene Symbol | SCN4A |
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Entrez Gene | 6329 |
Alt Symbol | HOKPP2, HYKPP, HYPP, NAC1A, Na(V)1.4, Nav1.4, SkM1 |
Species | Human |
Gene Type | protein-coding |
Description | sodium channel, voltage gated, type IV alpha subunit |
Other Description | skeletal muscle voltage-dependent sodium channel type IV alpha subunit|sodium channel protein skeletal muscle subunit alpha|sodium channel protein type 4 subunit alpha|sodium channel protein type IV subunit alpha|sodium channel, voltage-gated, type IV, alpha subunit|voltage-gated sodium channel subunit alpha Nav1.4 |
Swissprots | Q15478 Q16447 Q7Z6B1 P35499 |
Accessions | AAA75557 AAB21450 AAB59624 AAC14673 AAG43105 EAW94225 EAW94226 P35499 AY212253 AAO83647 BC172375 AAI72375 HG509334 M81758 AAA60554 XM_005257566 XP_005257623 NM_000334 NP_000325 |
Function | This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. This sodium channel may be present in both denervated and innervated skeletal muscle. |
Subcellular Location | Membrane; Multi-pass membrane protein. |
Na + CP type IVα CRISPR/Cas9 KO Plasmid (h) - sc-409192 from Santa Cruz Biotechnology
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Na + CP type IVα HDR Plasmid (h) - sc-409192-HDR from Santa Cruz Biotechnology
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Na + CP type IVα Double Nickase Plasmid (h) - sc-409192-NIC from Santa Cruz Biotechnology
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Na + CP type IVα Double Nickase Plasmid (h2) - sc-409192-NIC-2 from Santa Cruz Biotechnology
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Na + CP type IVα CRISPR Activation Plasmid (h) - sc-409192-ACT from Santa Cruz Biotechnology
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Na + CP type IVα CRISPR Activation Plasmid (h2) - sc-409192-ACT-2 from Santa Cruz Biotechnology
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Na + CP type IVα Lentiviral Activation Particles (h) - sc-409192-LAC from Santa Cruz Biotechnology
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Na + CP type IVα Lentiviral Activation Particles (h2) - sc-409192-LAC-2 from Santa Cruz Biotechnology
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Na + CP type IVα siRNA (h) - sc-42648 from Santa Cruz Biotechnology
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Na + CP type IV shRNA Plasmid (h) - sc-42648-SH from Santa Cruz Biotechnology
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Na + CP type IV shRNA (h) Lentiviral Particles - sc-42648-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU155051 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1680 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1680 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11202 from Sigma-Aldrich
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SCN4A siRNA (Human) - CRH4265 from Cohesion Biosciences
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SCN4A RNAi - H00006329-R01 from Novus Biologicals
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SCN4A - MBS8213974 from MyBioSource
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shRNA set against Human SCN4A (NM_000334.4) - SHH402856 from Creative biogene
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shRNA set against Human SCN4A(NM_000334.4) - SHR209064 from Creative biogene
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Human SCN4A siRNA - orb264767 from Biorbyt
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SCN4A shRNA Plasmid (Human) - CHH4265 from Cohesion Biosciences
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SCN4A miRNA 3'UTR clone - MiUTR1H-09188 from Creative biogene
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