| Gene Symbol |
RB1
|
| Entrez Gene |
5925
|
| Alt Symbol |
OSRC, PPP1R130, RB, p105-Rb, pRb, pp110
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
retinoblastoma 1
|
| Other Description |
prepro-retinoblastoma-associated protein|protein phosphatase 1, regulatory subunit 130|retinoblastoma suspectibility protein|retinoblastoma-associated protein
|
| Swissprots |
Q8IZL4 P78499 A8K5E3 P06400 Q5VW46
|
| Accessions |
AAA53483 AAA53484 AAA65735 AAA65736 AAA65737 AAA65738 AAA65739 AAA65740 AAA65741 AAA65742 AAA65743 AAA65744 AAA65745 AAA65746 AAA65747 AAA65748 AAA65749 AAA65998 AAA82538 AAA82539 AAA82540 AAA82541 AAA82542 AAA82543 AAA82544 AAA82545 AAA82546 AAA82547 AAA82548 AAA82549 AAA82550 AAA82551 AAA82552 AAA82553 AAA82554 AAA82555 AAA82556 AAA82557 AAA82558 AAA82559 AAA82560 AAA82561 AAA82562 AAA82563 AAB59466 AAB59467 AAB59468 AAB59469 AAB59470 AAB59471 AAB59472 AAB59473 AAB59474 AAB59475 AAB59476 AAB59477 AAB59478 AAB59479 AAB59480 AAB59481 AAB59482 AAB59483 AAB59489 AAB59579 AAB59580 AAN41646 AAN64133 AAO62758 AAP39867 AAT66036 AAT77205 AAT77206 AAT77207 AAV84025 ABC47164 CAA34462 EAX08793 EAX08794 P06400 AB208788 BAD92025 AF043224 AAC26845 AK291258 BAF83947 AK299179 BAG61225 AK300284 BAG62042 AK307125 AK307730 AY429568 BC039060 AAH39060 BC040540 AAH40540 DQ891564 ABM82490 DQ894752 ABM85678 L41870 AAB59465 M15400 AAA69807 M19701 AAA60259 M28419 AAA69808 M33647 AAA69806 XM_011535171 XP_011533473 NM_000321 NP_000312
|
| Function |
Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor compl
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:20940255}.
|
| Tissue Specificity |
Expressed in the retina.
|
| Top Pathways |
Cell cycle, Prostate cancer, Glioma, Pancreatic cancer, Non-small cell lung cancer
|